A new indolizinium alkaloid from marine-derived Streptomyces sp. HNA39. Issue 9 (2nd September 2021)

• Record Type: Journal Article
• Authors: Cheng, Xiang-Wei; Li, Jia-Qi; Jiang, Yong-Jun; Liu, Hua-Zhang; Huo, Chao
• Is Part Of: Journal of Asian natural products research. Volume 23:Issue 9(2021)
• Page Start: 913
• Page End: 918
• Publication Date: 2021-09-02
• Subjects: Streptomyces sp -- indolizinium alkaloid -- cyclizidine J; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2020.1799987
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: A new indolizinium alkaloid, named as cyclizidine J (1 ), was identified from Gause's liquid fermentation of marine-derived Streptomyces sp. HNA39. Its structure was elucidated by extensive NMR spectroscopic methods, HRESIMS data, and ECD calculations. To our best knowledge, compound 1 was a unique cyclizidine-type alkaloid that contain a chlorine atom substituted at position C-8. Unfortunately, biological evaluation of 1 exhibited no active against PC-3 cancer cell line, BRD4, and ROCK2 protein kinase. Graphical abstract: UF0001