Increased expression of lncRNA SNHG7 promotes the cell viability, migration, and invasion in pre-eclampsia via modulating the miR-214-5p/TWIST1 axis. (3rd July 2021)

• Record Type: Journal Article
• Authors: Wang, Yongping; Zhang, Zhihui
• Is Part Of: Hypertension in pregnancy. Volume 40:Number 3(2021)
• Page Start: 261
• Page End: 270
• Publication Date: 2021-07-03
• Subjects: Pre-eclampsia -- lncRNA snhg7 -- miR-214-5p -- twist1; Hypertension in pregnancy -- Periodicals; Pregnancy -- Complications -- Periodicals; 618.3261
• DOI: 10.1080/10641955.2021.1981372
• Languages: English
• ISSNs: 1064-1955

Abstract

ABSTRACT: Purpose: This study is aimed to elucidate the molecular mechanism of lncRNA SNHG7 on pre-eclampsia (PE). Methods: The expression of SNHG7, miR-214-5p and TWIST1 in PE placental tissues was detected by qRT-PCR. The regulatory mechanism of SNHG7/miR-214-5p/TWIST1 axis on PE was determined using MTT, wound healing, transwell invasion, and western blot assays. Results: In PE pregnancies, SNHG7 and TWIST1 were decreased, while miR-214-5p was increased.The elevated miR-214-5p and decreased TWIST1 partly eliminated the promoting effects of SNHG7 up-regulation on the viability and metastasis of JEG-3 cells. Conclusions: Up-regulated SNHG7 protects against PE through modulating the miR-214-5p/TWIST1 axi.