Low morbidity in Danish patients with common variable immunodeficiency disorder infected with severe acute respiratory syndrome coronavirus 2. Issue 12 (2nd December 2021)

• Record Type: Journal Article
• Authors: Drabe, Camilla Heldbjerg; Hansen, Ann-Brit Eg; Rasmussen, Line Dahlerup; Larsen, Olav Ditlevsen; Møller, Axel; Mogensen, Trine H.; Helweg-Larsen, Jannik; Katzenstein, Terese L.
• Is Part Of: Infectious diseases. Volume 53:Issue 12(2021)
• Page Start: 953
• Page End: 958
• Publication Date: 2021-12-02
• Subjects: COVID-19 -- SARS-CoV-2 -- common variable immunodeficiency -- primary immunodeficiency -- inborn errors of immunity; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; 616.9
• DOI: 10.1080/23744235.2021.1957144
• Languages: English
• ISSNs: 2374-4235

Abstract

Abstract: Background: Manifestations and outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are not well documented in patients with common variable immunodeficiency disorder (CVID). Methods: A Danish nationwide retrospective clinician-reported survey. Results: Eleven patients with CVID and SARS-CoV-2 infection were identified. The median age was 50 years (range 22–72). All were on immunoglobulin replacement therapy. Eight patients had other pre-existing co-morbidities. Three patients were asymptomatic during the SARS-CoV-2 infection while seven developed mild coronavirus disease 2019 (COVID-19). One patient had more severe disease with hypoxia and required oxygen therapy. This patient had multiple co-morbidities including well known risk factors for severe COVID-19. All patients recovered. Conclusions: The results suggest that CVID may not be a risk factor for severe COVID-19. However, further monitoring of this immunodeficient population is needed to confirm our observation.