Iminyl-radicals by electrochemical decarboxylation of α-imino-oxy acids: construction of indole-fused polycyclics. Issue 79 (16th September 2021)

• Record Type: Journal Article
• Authors: Wan, Jin-Lin; Cui, Jian-Feng; Zhong, Wei-Qiang; Huang, Jing-Mei
• Is Part Of: Chemical communications. Volume 57:Issue 79(2021)
• Page Start: 10242
• Page End: 10245
• Publication Date: 2021-09-16
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc03891e
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An electrochemical decarboxylation/N–O bond cleavage of α-imino-oxy acids was achieved to build up N-heterocycles via iminyl radicals. Abstract : Iminyl radicals are reactive intermediates that can be used for the construction of various valuable heterocycles. Herein, the electrochemical decarboxylation of α-imino-oxy acids for the generation of iminyl radicals has been accomplished under exogenous-oxidant- and metal-free conditions through the use of n Bu4 NBr as a mediator. The resulting iminyl radicals undergo intramolecular cyclization smoothly with the adjacent (hetero)arenes to afford a series of indole-fused polycyclic compounds.