Smart near infrared-responsive nanocomposite hydrogels for therapeutics and diagnostics. Issue 35 (2nd July 2021)

• Record Type: Journal Article
• Authors: Shen, Ke-Han; Lu, Cheng-Hsun; Kuo, Chih-Yu; Li, Bo-Yan; Yeh, Yi-Cheun
• Is Part Of: Journal of materials chemistry. Volume 9:Issue 35(2021)
• Page Start: 7100
• Page End: 7116
• Publication Date: 2021-07-02
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d1tb00980j
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : This review article highlights recent research progress on the NIR-responsive nanocomposite hydrogels, focusing on their preparation, properties, applications and future prospectus. Abstract : Nanocomposite (NC) hydrogels are emerging biomaterials that possess desirable and defined properties and functions for therapeutics and diagnostics. Particularly, nanoparticles (NPs) are employed as stimulus-transducers in NC hydrogels to facilitate the treatment process by providing controllable structural change and payload release under internal and external simulations. Among the various external stimuli, near-infrared (NIR) light has attracted considerable interest due to its minimal photo-damage, deep tissue penetration, low auto-fluorescence in living systems, facile on/off switch, easy remote and spatiotemporal control. In this study, we discuss four types of transducing nanomaterials used in NIR-responsive NC hydrogels, including metal-based nanoparticles, carbon-based nanomaterials, polydopamine nanoparticles (PDA NPs), and upconversion nanoparticles (UCNPs). This review provides an overview of the current progress in NIR-responsive NC hydrogels, focusing on their preparation, properties, applications, and future prospects.