Iron-catalyzed radical cascade cyclization of oxime esters with isocyanides: synthesis of 1-cyanoalkyl isoquinolines and 6-cyanoalkyl phenanthridines. Issue 39 (23rd September 2021)

• Record Type: Journal Article
• Authors: Xue, Dengqi; Liu, Rongqi; Zhang, Denggao; Li, Ning; Xue, Yijie; Ge, Qianwei; Shao, Liming
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 39(2021)
• Page Start: 8597
• Page End: 8606
• Publication Date: 2021-09-23
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d1ob01556g
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An iron-catalyzed radical cascade cyclization of oxime esters with isocyanides for the synthesis of 1-cyanoalkyl isoquinolines and 6-cyanoalkyl phenanthridines has been developed. Abstract : An iron-catalyzed radical cascade cyclization of oxime esters with isocyanides for the synthesis of 1-cyanoalkyl isoquinolines and 6-cyanoalkyl phenanthridines has been developed. This demonstrates excellent functional group tolerance and broad substrate scope. A diverse range of potentially valuable 1-cyanoalkyl isoquinolines and 6-cyanoalkyl phenanthridines were obtained in moderate to good yields.