Glaucoma following cataract surgery in the first 2 years of life: frequency, risk factors and outcomes from IoLunder2. Issue 7 (5th October 2019)

• Record Type: Journal Article
• Authors: Solebo, Ameenat Lola; Rahi, Jugnoo S
• Other Names: author non-byline.; Abbott Joseph author non-byline.; Parulekar Manoj author non-byline.; Ainsworth John author non-byline.; Adams Gillian W author non-byline.; Theodorou Maria author non-byline.; Hancox Joanne author non-byline.; Dahlmann-Noor Annegret author non-byline.; Khaw Peng author non-byline.; Allen Louise author non-byline.; Amaya Luis author non-byline.; Anwar Samira author non-byline.; Ashworth Jane author non-byline.; Biswas Susmito author non-byline.; Barry John author non-byline.; Bloom Phillip author non-byline.; Bowman Richard author non-byline.; Russell-Eggitt Isabelle author non-byline.; Moore William author non-byline.; Moore Anthony T author non-byline.; Bradbury John author non-byline.; Pilling Rachel author non-byline.; Gout Taras author non-byline.; Brosnahan Donal author non-byline.; Butcher Jeremy author non-byline.; Jonathan Chan TK author non-byline.; Chandna Arvind author non-byline.; Choi Jessy author non-byline.; Churchill Amanda J author non-byline.; Clarke Mike P author non-byline.; Shafiq Ayad author non-byline.; Dean Fiona author non-byline.; Dutton Gordon author non-byline.; Elston John author non-byline.; Ferris John author non-byline.; Fleck Brian author non-byline.; George Nick D author non-byline.; Gnanaraj Lawrence author non-byline.; Gregson Richard author non-byline.; Jones David author non-byline.; Joseph Annie author non-byline.; Laws David author non-byline.; Lavy Tim author non-byline.; Lloyd Ian Chris author non-byline.; Long Vernon author non-byline.; MacCrae Mary author non-byline.; MacKinnon Jane author non-byline.; Marr Jane author non-byline.; May Kristina author non-byline.; Self Jay author non-byline.; Loone Eibhlin Mc author non-byline.; McGinnity Gerry author non-byline.; Mulvihill Alan author non-byline.; Newman William author non-byline.; Mansor Qasim author non-byline.; Porooshani Haamid author non-byline.; Pauw Jacobus author non-byline.; Puvanachandra Narman author non-byline.; Quinn Anthony G author non-byline.; Roberts Clare author non-byline.; Scott Christopher author non-byline.; Soeldner Hans author non-byline.; Sleep Tamsin author non-byline.; Taylor David SI author non-byline.; Taylor Robert H author non-byline.; Watts Patrick author non-byline.; Aclimandos Wagih author non-byline.; Aguirre Vila-Coro A author non-byline.; Williams Cathy author non-byline.; Armstrong Simon author non-byline.; Astbury Nick author non-byline.; Bates Adam author non-byline.; Bedford Godfrey author non-byline.; Boyle Natalie author non-byline.; Benjamin Larry author non-byline.; Billington Brenda author non-byline.; Blaikie Andrew author non-byline.; Brazier John author non-byline.; Bron Anthony author non-byline.; Bryan Stephen author non-byline.; Burke John author non-byline.; Butler Lucilla author non-byline.; Casswell Anthony author non-byline.; Condon Richard author non-byline.; Corridan Patrick author non-byline.; Das Bichitra author non-byline.; Daya Sheraz author non-byline.; Cock Romain De author non-byline.; Dees Chrisjan author non-byline.; Edelsten Clive author non-byline.; El-Kabasy Hisam author non-byline.; Evans Anthony author non-byline.; Evans Nick author non-byline.; Gaskell Andrew author non-byline.; Gibbens Mary author non-byline.; Gibbons Caspar author non-byline.; Gregory Peter author non-byline.; Hakim Jamil author non-byline.; Hardman-Lea Stephen author non-byline.; Hassan Mohammed author non-byline.; Heravi Mohammad author non-byline.; Hingorani Melanie author non-byline.; Holden Roger author non-byline.; Humphrey Roger author non-byline.; Innes Jim author non-byline.; Jenkins Chris author non-byline.; Kayali Nuka author non-byline.; Keightley Simon author non-byline.; Kostakis Anastassios author non-byline.; Kotta Satish author non-byline.; Kumar Rajakopal author non-byline.; Leitch Jane author non-byline.; Liu Christopher author non-byline.; MacEwen Carrie author non-byline.; Moriarty Brendan author non-byline.; Morris Robert author non-byline.; Neugebager Mark author non-byline.; O'Connor Gerard author non-byline.; Ohri Rita author non-byline.; Perry Stephen author non-byline.; Reddy Aravind author non-byline.; Scotcher Stephen author non-byline.; Scott James author non-byline.; Sellar Peter author non-byline.;
• Is Part Of: British journal of ophthalmology. Volume 104:Issue 7(2020)
• Page Start: 967
• Page End: 973
• Publication Date: 2019-10-05
• Subjects: child health (paediatrics) -- lens and zonules -- glaucoma -- treatment surgery -- vision; Ophthalmology -- Periodicals; 617.7
• DOI: 10.1136/bjophthalmol-2019-314804
• Languages: English
• ISSNs: 0007-1161

Abstract

Abstract : Background: We investigated glaucoma related adverse events, predictors and impact at 5 years following surgery in the IoLunder2 cohort Methods: Population based observational cohort study of children undergoing cataract surgery aged 2 years or under between January 2009 and December 2010. Glaucoma was defined using internationally accepted taxonomies based on the consequences of elevated intraocular pressure (IOP). Glaucoma related adverse events were any involving elevated IOP. Multivariable analysis was undertaken to investigate potential predictors of secondary glaucoma with adjustment for within-child correlation in bilateral cataract. Unilateral and bilateral cataract were analysed separately. Results: Complete follow-up data were available for 235 of 254, 93% of the inception cohort. By 5 years after primary cataract surgery, 20% of children with bilateral cataract and 12% with unilateral had developed secondary glaucoma. Glaucoma related complications had been diagnosed in 24% and 36% of children, respectively. Independent predictors of glaucoma were younger age at surgery (adjusted OR for reduction of week in age: 1.1, 95%C I 1.1 to 1.2, p<0.001); the presence of significant ocular comorbidity (adj OR 3.2, 95% CI 1.1 to 9.6, p=0.01); and shorter axial length (adj OR for each mm 1.7, 95% CI 10.0 to 1, p=0.05) for bilateral cataract. Shorter axial length was the single independent factor in unilateral disease (adj OR 9.6, 95% CI 1.7 to 52, p=0.009) Conclusions: Both younger age at surgery (the strongest marker of ocular 'immaturity') and smaller ocular size (a marker of both immaturity and developmental vulnerability) can be used to identify those at greatest risk of glaucoma due to early life cataract surgery.