A green and sustainable approach for the synthesis of 1, 5-benzodiazepines and spirooxindoles in one-pot using a MIL-101(Cr) metal–organic framework as a reusable catalyst. (8th October 2021)

• Record Type: Journal Article
• Authors: Sarkar, Fillip Kumar; Gupta, Ajay; Jamatia, Ramen; Anal, Jasha Momo H.; Pal, Amarta Kumar
• Is Part Of: New journal of chemistry. Volume 45:Number 41(2021)
• Page Start: 19553
• Page End: 19564
• Publication Date: 2021-10-08
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/d1nj03176g
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : Green and efficient protocols for the synthesis of 1, 5-benzodiazepines and spirooxindoles were developed utilizing MIL-101(Cr) in SFRC and water as solvent respectively. Abstract : Metal–organic framework MIL-101(Cr) has been efficiently utilized for the synthesis of biologically relevant heterocycles such as 1, 5-benzodiazepines and spirooxindoles in one-pot. MIL-101(Cr) was prepared via a solvothermal method and characterized by FT-IR, PXRD, SEM, TEM, EDX, and ICP-OES analysis. Thermogravimetric analysis (TGA) described its high thermal stability. Low catalyst loading, easy separation, reusability, and high yields are some salient features of the protocols. Solvent-free reaction conditions (SFRC) or water as solvent are some additional benefits in the field of green and sustainable process development.