Access to acridones by tandem copper(i)-catalyzed electrophilic amination/Ag(i)-mediated oxidative annulation of anthranils with arylboronic acids. Issue 39 (21st September 2021)

• Record Type: Journal Article
• Authors: Jiang, Chun-Yong; Xie, Hui; Huang, Zhuo-Jun; Liang, Jing-Yi; Huang, Yan-Xia; Liang, Qiu-Ping; Zeng, Jun-Yi; Zhou, Binhua; Zhang, Shang-Shi; Shu, Bing
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 39(2021)
• Page Start: 8487
• Page End: 8491
• Publication Date: 2021-09-21
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d1ob01586a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An efficient and practical approach for the synthesis of medicinally important acridones was developed from anthranils and arylboronic acids by a tandem copper(i )-catalyzed electrophilic amination/Ag(i )-mediated oxidative annulation strategy. Abstract : An efficient and practical approach for the synthesis of medicinally important acridones was developed from anthranils and commercially available arylboronic acids by a tandem copper(i )-catalyzed electrophilic amination/Ag(i )-mediated oxidative annulation strategy. This new and straightforward protocol displayed a broad substrate scope (25 examples) and high functional group tolerance. What's more, a possible mechanistic proposal was also presented.