Differences in the management and survival of metastatic colorectal cancer in Europe. A population-based study. Issue 5 (May 2021)

• Record Type: Journal Article
• Authors: Bouvier, Anne-Marie; Jooste, Valérie; Sanchez-Perez, Maria José; Bento, Maria José; Rocha Rodrigues, Jessica; Marcos-Gragera, Rafael; Carmona-Garcia, Maria Carmen; Luque-Fernandez, Miguel Angel; Minicozzi, Pamela; Bouvier, Véronique; Innos, Kaire; Sant, Milena; Van Eycken, L.; Henau, K.; Grozeva, T.; Valerianova, Z.; Innos, K.; Mägi, M.; Bouvier, V.; Launoy, G.; Robaszkiewicz, M.; Bouvier, A.M.; Jooste, V.; Babaev, V.; Katalinic, A.; Ólafsdóttir, E.J.; Tryggvadóttir, L.; Amati, C.; Baili, P.; Bonfarnuzzo, S.; Margutti, C.; Meneghini, E.; Minicozzi, P.; Moretti, G.; Sant, M.; Cirilli, C.; Carrozzi, G.; Spata, E.; Tumino, R.; Rossi, P. Giorgi; Vicentini, M.; Stracci, F.; Bianconi, F.; Contiero, P.; Tagliabue, G.; Kycler, W.; Oko, M.; Macek, P.; Smok-Kalwat, J.; Bielska-Lasota, M.; Kycler, W.; Oko, M.; Bento, M.J.; Rodrigues, J; Mayer-da-Silva, A.; Miranda, A.; Primic-Žakelj, M.; Jarm, K.; Almar, E.; Mateos, A.; Bidaurrazaga, J.; de la Cruz, M.; Alberich, C.; Torrella-Ramos, A.; García, J.M. Díaz; Marcos-Navarro, AI; Carmona-Garcia, C.; Marcos-Gragera, R.; Luque-Fernandez, M.A.; Sánchez-Pérez, M.J.; Ardanaz, E.; Guevara, M.; Bouchardy, C.; Fournier, E.;
• Is Part Of: Digestive and liver disease. Volume 53:Issue 5(2021)
• Page Start: 639
• Page End: 645
• Publication Date: 2021-05
• Subjects: Colorectal cancer -- Metastasis -- Registries -- Europe -- Survival -- Disease Management; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; 616.33005
• DOI: 10.1016/j.dld.2021.01.021
• Languages: English
• ISSNs: 1590-8658

Abstract

Abstract: Background: The management regarding metastatic colorectal cancer throughout Europe is not well known. Aims: To draw a European comparison of the management and prognosis of metastatic colorectal cancers. Methods: Factors associated with chemotherapy administration were identified through logistic regressions. Net survival was estimated and crude probabilities of death related to cancer and other causes using a flexible cumulative hazard model. Results: Among the 13 227 patients with colorectal cancer diagnosed between 2010 and 2013 in cancer registries from 10 European countries, 3140 were metastatic. 62% of metastatic patients received chemotherapy. Compared to Spain, the related adjusted odds ratios ranged from 0.7 to 4.0 (P<0.001) according to country. The 3-year net survival by country ranged between 16% and 37%. The survival gap between countries diminished from 21% to 10% when adjusting for chemotherapy, age and sex. Geographical differences in the crude probability of death related to cancer were large for patients <70 or ≥80 years at diagnosis. Conclusion: Heterogeneity in the application of European guidelines partly explain these differences. General health between populations, accessibility to a reference centre, or provision of health care could also be involved. Further population-based studies are warranted to disentangle between these possible explanations.