Unravelling the antimicrobial activity of peptide hydrogel systems: current and future perspectives. Issue 35 (31st August 2021)

• Record Type: Journal Article
• Authors: Cross, Emily R.; Coulter, Sophie M.; Pentlavalli, Sreekanth; Laverty, Garry
• Is Part Of: Soft matter. Volume 17:Issue 35(2021)
• Page Start: 8001
• Page End: 8021
• Publication Date: 2021-08-31
• Subjects: Soft condensed matter -- Periodicals; 530.413
• DOI: 10.1039/d1sm00839k
• Languages: English
• ISSNs: 1744-683X

Abstract

Abstract : The use of hydrogels has garnered significant interest as biomaterial and drug delivery platforms for anti-infective applications. Abstract : The use of hydrogels has garnered significant interest as biomaterial and drug delivery platforms for anti-infective applications. For decades antimicrobial peptides have been heralded as a much needed new class of antimicrobial drugs. Self-assembling peptide hydrogels with inherent antimicrobial ability have recently come to the fore. However, their fundamental antimicrobial properties, selectivity and mechanism of action are relatively undefined. This review attempts to establish a link between antimicrobial efficacy; the self-assembly process; peptide–membrane interactions and mechanical properties by studying several reported peptide systems: β-hairpin/β-loop peptides; multidomain peptides; amphiphilic surfactant-like peptides and ultrashort/low molecular weight peptides. We also explore their role in the formation of amyloid plaques and the potential for an infection etiology in diseases such as Alzheimer's. We look briefly at innovative methods of gel characterization. These may provide useful tools for future studies within this increasingly important field.