Human biomonitoring of essential, nonessential, rare earth, and noble elements in placental tissues. (December 2021)

• Record Type: Journal Article
• Authors: Stojsavljević, Aleksandar; Rovčanin, Marija; Rovčanin, Branislav; Miković, Željko; Jeremić, Ana; Perović, Milan; Manojlović, Dragan
• Is Part Of: Chemosphere. Volume 285(2021)
• Publication Date: 2021-12
• Subjects: Trace element -- Placental tissue -- Biomonitoring -- Reference range; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2021.131518
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: Exposure to certain metals has been recognized as a risk factor for numerous complications in vulnerable population groups, particularly pregnant women. This investigation evaluated the levels of essential (Cr, Mn, Co, Cu, Zn, Se, Mo) and nonessential trace metals with recognized toxicity (Be, Al, Ti, V, Ni, Ga, As, Rb, Sr, Cd, Sb, Ba, Tl, Hg, Pb, Bi, Th, U), together with rare earth elements (Sc, Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Yb, Lu), and noble metals (Ru, Rh, Pd, Re, Os, Ir, Pt, Au, Ag) in the placental tissues of healthy pregnant women (n = 105). The selection of participants was undertaken with special reference to specific confounding factors that could influence the trace element profiles. Among trace elements, Zn was the most abundant and Lu was the least abundant. Cd and Os placental levels show a tendency to increase with women's age. Compared with literature data, high levels of Ni were found. This is the first study that provides the composition levels of essential and toxic trace elements, rare earth elements, and noble metals in human placental tissues. Also, for the first time, normal (reference) ranges for 50 (ultra)trace elements in placental tissues are proposed. Reference ranges are especially important in biomonitoring studies, which nowadays give increasing importance to the analysis of solid tissues instead of body fluids. Overall, the information provided in this study can serve as a starting point for further clinical trials and/or prediction of potential risks to pregnancy. Graphical abstract: Image 1 Highlights: Placental levels of 50 (ultra)trace elements were resolved. Reference values for essential, toxic, rare earth and noble metals were created. Zn was the most abundant and Lu was the least abundant. Placental levels of Cd and Os appear to be age-dependent. Compared with literature data, high placental Ni levels were found.