Copper-catalyzed domino synthesis of ynamines. Issue 36 (31st August 2021)

• Record Type: Journal Article
• Authors: Rao, Maddali L. N.; Islam, Sk Shamim; Dasgupta, Priyabrata
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 36(2021)
• Page Start: 7855
• Page End: 7860
• Publication Date: 2021-08-31
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d1ob01383a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A Cu-catalyzed domino protocol using gem -dibromoalkenes and N-heteroarenes is developed for the synthesis of ynamines and it is applied in the synthesis of enynamines, bis/tris-ynamines and peyonine natural product. Abstract : The hitherto unexplored N -alkynylation of electron-withdrawing or protecting group free N-heteroarenes such as indole, carbazole and pyrrole was developed using gem -dibromoalkenes to synthesize ynamines under ligand-free copper-catalyzed domino conditions. The development methodology of ynamines was also applied in the synthesis of enynamines, multi-coupled bis-ynamines, tris-ynamines, and the natural product peyonine, demonstrating its broad synthetic scope and applications.