CO2-tuned highly selective reduction of formamides to the corresponding methylamines. Issue 19 (21st September 2021)

• Record Type: Journal Article
• Authors: Guo, Zhiqiang; Pang, Tengfei; Yan, Leilei; Wei, Xuehong; Chao, Jianbin; Xi, Chanjuan
• Is Part Of: Green chemistry. Volume 23:Issue 19(2021)
• Page Start: 7534
• Page End: 7538
• Publication Date: 2021-09-21
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/d1gc02815d
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : An efficient, CO2 -tuned and highly selective C–O bond cleavage of N -methylated formanilides with NaBH4 has been achieved. Notably, when using N2 as reaction atmosphere, the reaction gave N -methylaniline as major product via C–N bond hydrogenolysis. Abstract : We herein describe an efficient, CO2 -tuned and highly selective C–O bond cleavage of N -methylated formanilides. With easy-to-handle and commercially available NaBH4 as the reductant, a variety of formanilides could be turned into the desired tertiary amines in moderate to excellent yields. The role of CO2 has been investigated in detail, and the mechanism is proposed on the basis of experiments.