Traditional uses, phytochemistry, pharmacology, and toxicology of Pterocephalus hookeri (C. B. Clarke) Höeck: a review. Issue 46 (26th August 2021)

• Record Type: Journal Article
• Authors: Gan, Zhiqiang; Jiang, Juan; Tao, Honglin; Luo, Shiying; Meng, Xianli; Yu, Jia; Zhang, Yi; Tang, Ce
• Is Part Of: RSC advances. Volume 11:Issue 46(2021)
• Page Start: 28761
• Page End: 28774
• Publication Date: 2021-08-26
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d1ra05548h
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Pterocephalus hookeri (C. B. Clarke) Höeck has been used in traditional Tibetan medicine for thousands of years. The existing research results of P. hookeri are summarized, and will provide a basis for the further development of new drugs. Abstract : Pterocephalus hookeri (C. B. Clarke) Höeck is a member of the Dipsacaceae family and has been used in traditional Tibetan medicine for thousands of years. P. hookeri clears heat, detoxifies, stops dysentery, eliminates distemper, dispels wind, and relieves stagnation and is mainly prescribed for heat syndrome, dysentery, arthritis, and plague. Approximately 93 chemical compounds have been isolated and identified from P. hookeri, including iridoid glycosides, lignan and triterpenoids. Meanwhile, modern pharmacological studies have shown that P. hookeri has anti-inflammatory, anti-rheumatoid arthritis, analgesic, anticancer, and neuroprotection activities. However, studies on the in vivo pharmacokinetics and mechanism of action, discovery of quality markers, and qualitative and quantitative analysis are still insufficient. Hence, this paper provides a comprehensive review of the ethnic medicine, phytochemistry, pharmacology, and toxicology of P. hookeri to increase the understanding of the medicinal value of P. hookeri.