Safety of 6000 intravitreal dexamethasone implants. Issue 1 (30th April 2019)

• Record Type: Journal Article
• Authors: Rajesh, Bindu; Zarranz-Ventura, Javier; Fung, Adrian T; Busch, Catharina; Sahoo, Niroj Kumar; Rodriguez-Valdes, Patricio J; Sarao, Valentina; Mishra, Sanjay Kumar; Saatci, A Osman; Udaondo Mirete, Patricia; Querques, Giuseppe; Farah, Michel Eid; Lanzetta, Paolo; Arevalo, J Fernando; Kodjikian, Laurent; Chhablani, Jay
• Other Names: author non-byline.; Gupta A. author non-byline.; Singh A. author non-byline.; Goud Abhilash author non-byline.; mansour Ahmad author non-byline.; Banker Alay author non-byline.; Sen Alok C author non-byline.; Marashi Ameen author non-byline.; Maia Andre author non-byline.; Maiti Aniruddha author non-byline.; Sharma Ashish author non-byline.; Cagini Carlo author non-byline.; Bernal-Morales Carolina author non-byline.; Sarvaiya Chintan author non-byline.; Veritti Daniele author non-byline.; Zur Dinah author non-byline.; Masarwa Dua author non-byline.; Novais Eduardo author non-byline.; Giancipoli Ermete author non-byline.; Bandello Francesco author non-byline.; Al-khersan Hasenin author non-byline.; Wong J S author non-byline.; Raji K. author non-byline.; Wu Lihteh author non-byline.; Okada Mali author non-byline.; Nagpal Manish author non-byline.; Casella Marcelo author non-byline.; Lupidi Marco author non-byline.; Avila Marcos author non-byline.; Berrocal Maria author non-byline.; Iglicki Matias author non-byline.; Maia Mauricio author non-byline.; Cavalleri Michele author non-byline.; Rasheed Mohammed Abdul author non-byline.; Asencio-Duran Monica author non-byline.; Rassu Nicolò author non-byline.; D'Anna-Mardero Oriana author non-byline.; Gabrielle Pierre-Henry author non-byline.; Shenoy Prateek author non-byline.; Gallego-Pinazo Roberto author non-byline.; Marco Rosa Dolz author non-byline.; Kumar S. author non-byline.; Patyal S. author non-byline.; Fraser-Bell Samantha author non-byline.; Cohen Shai author non-byline.; Singh Sumit Randhir author non-byline.; Sharma V. author non-byline.; Sarao Valentina author non-byline.; Chaikitmongkol Voraporn author non-byline.; Cebeci Zafer author non-byline.; Ayhan Ziya author non-byline.; Bernal-Morales Carolina author non-byline.; Sarvaiya Chintan author non-byline.; Veritti Daniele author non-byline.; Zur Dinah author non-byline.; Masarwa Dua author non-byline.; Novais Eduardo author non-byline.; Giancipoli Ermete author non-byline.; Bandello Francesco author non-byline.; Al-khersan Hasenin author non-byline.; Wong J S author non-byline.; Raji K. author non-byline.; Wu Lihteh author non-byline.; Okada Mali author non-byline.; Nagpal Manish author non-byline.; Casella Marcelo author non-byline.; Lupidi Marco author non-byline.; Avila Marcos author non-byline.; Berrocal Maria author non-byline.; Iglicki Matias author non-byline.; Maia Mauricio author non-byline.; Cavalleri Michele author non-byline.; Rasheed Mohammed Abdul author non-byline.; Asencio-Duran Monica author non-byline.; Rassu Nicolò author non-byline.; D'Anna-Mardero Oriana author non-byline.; Gabrielle Pierre-Henry author non-byline.; Shenoy Prateek author non-byline.; Gallego-Pinazo Roberto author non-byline.; Marco Rosa Dolz author non-byline.; Kumar S. author non-byline.; Patyal S. author non-byline.; Fraser-Bell Samantha author non-byline.; Cohen Shai author non-byline.; Singh Sumit Randhir author non-byline.; Sharma V. author non-byline.; Sarao Valentina author non-byline.; Chaikitmongkol Voraporn author non-byline.; Cebeci Zafer author non-byline.; Ayhan Ziya author non-byline.; Bernal-Morales Carolina author non-byline.; Sarvaiya Chintan author non-byline.; Veritti Daniele author non-byline.; Zur Dinah author non-byline.; Masarwa Dua author non-byline.; Novais Eduardo author non-byline.; Giancipoli Ermete author non-byline.; Bandello Francesco author non-byline.; Al-khersan Hasenin author non-byline.; Wong J S author non-byline.; Wu Lihteh author non-byline.; Okada Mali author non-byline.; Nagpal Manish author non-byline.; Casella Marcelo author non-byline.; Lupidi Marco author non-byline.; Avila Marcos author non-byline.; Berrocal Maria author non-byline.; Iglicki Matias author non-byline.; Maia Mauricio author non-byline.; Cavalleri Michele author non-byline.; Rasheed Mohammed Abdul author non-byline.; Asencio-Duran Monica author non-byline.; Rassu Nicolò author non-byline.; D'Anna-Mardero Oriana author non-byline.; Gabrielle Pierre-Henry author non-byline.; Shenoy Prateek author non-byline.; Gallego-Pinazo Roberto author non-byline.; Marco Rosa Dolz author non-byline.; Kumar S. author non-byline.; Fraser-Bell Samantha author non-byline.; Cohen Shai author non-byline.; Singh Sumit Randhir author non-byline.; Sharma V. author non-byline.; Sarao Valentina author non-byline.; Chaikitmongkol Voraporn author non-byline.; Cebeci Zafer author non-byline.; Ayhan Ziya author non-byline.;
• Is Part Of: British journal of ophthalmology. Volume 104:Issue 1(2020)
• Page Start: 39
• Page End: 46
• Publication Date: 2019-04-30
• Subjects: drugs -- treatment medical -- vitreous -- vision; Ophthalmology -- Periodicals; 617.7
• DOI: 10.1136/bjophthalmol-2019-313991
• Languages: English
• ISSNs: 0007-1161

Abstract

Abstract : Purpose: To evaluate the real-life safety profile of intravitreal dexamethasone implant injection for various retinal conditions. Methods: Retrospective multicenter analysis of intravitreal dexamethasone implant injections (700 µg) due to various retinal conditions including central retinal venous occlusion (1861 injections), diabetic macular oedema (3104 injections), post-surgical cystoid macular oedema (305 injections) and uveitis (381 injections). The eyes were evaluated mainly for the occurrence of adverse events such as glaucoma, cataract, retinal detachment and endophthalmitis along during the follow-up period. Results: A total of 6015 injections in 2736 eyes of 1441 patients (mean age of 65.7±12.9 years) were in total analysed over an average period of 18 months (range 6 months to 102 months). A total of 576 eyes (32.5% of the phakic eyes) developed cataract requiring surgical intervention. However, visually insignificant cataract progression was observed in another 259 phakic eyes (14.6%) which did not require surgical removal. A total of 727 eyes (26.5%) experienced an intraocular pressure (IOP) rise of >25 mm Hg, with 155 eyes (5.67%) having a prior history of glaucoma and 572 eyes (20.9%) having new onset IOP rise. Overall, more than 90% of eyes with IOP rise were managed medically, and 0.5% eyes required filtering surgery. Endophthalmitis (0.07%), retinal detachment (0.03%) and vitreous haemorrhage (0.03%) were rare. There was no significant change in visual acuity (p=0.87) and central macular thickness (p=0.12) at the last follow-up. Conclusion: This is the largest real-life study assessing the safety of intravitreal dexamethasone implant injections in various retinal conditions. Cataract progression and intraocular pressure rise are the most common side effects, but are often rather easily manageable.