I2-Catalyzed oxidative dehydrogenative tandem cyclization of 2-methylquinolines, arylamines and 1, 4-dioxane. Issue 21 (14th September 2021)

• Record Type: Journal Article
• Authors: Qi, Hongrui; Yan, Yiyan; Liao, Yunfeng; Jiang, Furong; Gao, Hualan; Deng, Guo-Jun
• Is Part Of: Organic chemistry frontiers. Volume 8:Issue 21(2021)
• Page Start: 6108
• Page End: 6113
• Publication Date: 2021-09-14
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d1qo01125a
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A novel I2 -catalyst oxidative dehydrogenative tandem cyclization of 2-methylquinolines, arylamines and 1, 4-dioxane for the construction of 2-([2, 2′-biquinolin]-3-yloxy)ethan-1-ol derivatives has been developed under metal-free conditions. Abstract : A novel I2 -catalyst oxidative dehydrogenative tandem cyclization of three components, 2-methylquinolines, arylamines and 1, 4-dioxane, for the construction of 2-([2, 2′-biquinolin]-3-yloxy)ethan-1-ol derivatives has been developed under metal-free conditions. This transformation with the cleavage of 7 C–H bonds, 2 N–H bonds and 1 C–O bond leads to the construction of 2 C–C bonds, 1 C–N bond and 1 O–H bond. The 1, 4-dioxane ring was opened and a 2-(vinyloxy)ethan-1-ol group was obtained in the whole process.