Evaluation of vascular changes in intermediate uveitis and retinal vasculitis using swept-source wide-field optical coherence tomography angiography. Issue 9 (11th December 2018)

• Record Type: Journal Article
• Authors: Tian, Meng; Tappeiner, Christoph; Zinkernagel, Martin S; Huf, Wolfgang; Wolf, Sebastian; Munk, Marion R
• Is Part Of: British journal of ophthalmology. Volume 103:Issue 9(2019)
• Page Start: 1289
• Page End: 1295
• Publication Date: 2018-12-11
• Subjects: intermediate uveitis -- retinal vasculitis -- optical coherence tomography angiography (OCTA) -- fluorescein angiography; Ophthalmology -- Periodicals; 617.7
• DOI: 10.1136/bjophthalmol-2018-313078
• Languages: English
• ISSNs: 0007-1161

Abstract

Abstract : Purpose: To evaluate vascular changes in patients with intermediate uveitis with or without retinal vasculitis using swept-source wide-field optical coherence tomography angiography (OCTA). Methods: This is a prospective cross-sectional study. Consecutive patients with intermediate uveitis were evaluated using wide-field OCTA. Wide-field OCTA and en-face OCT images were analysed for the presence of capillary non-perfusion and reduced perfusion, disruption of ellipsoid zone, and abnormalities on en-face wide-field retinal thickness maps, respectively, and compared with fluorescein angiography (FA) findings in a subcohort. Results: 164 eyes of 88 patients with intermediate uveitis were included. Areas of capillary non-perfusion and reduced perfusion were more frequently observed in the choroidal OCTA slab (33.3% and 49.4%), choriocapillaris (CC; 31.4% and 48%) and deep capillary plexus (DCP; 9.6% and 34.6%) than in the superficial capillary plexus (SCP; 5% and 26.3%), respectively. Intermediate uveitis with vasculitis presented more frequently with non-perfusion and hypoperfusion in the DCP (p=0.003 and p=0.05, respectively) and SCP (p=0.007 and p=0.005, respectively) than intermediate uveitis without vasculitis. Peripheral capillary leakage on FA correlated with the presence of perivascular, macular and generalised thickening on en-face wide-field thickness maps (p=0.007). Ischaemia on FA was significantly associated with non-perfusion on wide-field OCTA in SCP and DCP (p=0.019 and p=0.027, respectively). Conclusion: Changes in the choroid, CC and DCP are more frequently found than in the SCP on wide-field OCTA in intermediate uveitis. While wide-field OCTA is a reliable tool to detect capillary non-perfusion in intermediate uveitis, it was not helpful in determining disease activity. Trial registration number: NCT02811536 .