Diversity-oriented synthesis of imidazo[1, 2-a][1, 3, 5]triazine derivatives from 2-amine-[1, 3, 5]triazines with ketones. Issue 82 (28th September 2021)

• Record Type: Journal Article
• Authors: Zhao, Wanqiu; Zhang, Cheng; Zhong, Pengzhen; Zhou, Wei; Zhang, Chen; Cui, Dong-Mei
• Is Part Of: Chemical communications. Volume 57:Issue 82(2021)
• Page Start: 10715
• Page End: 10718
• Publication Date: 2021-09-28
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc04294g
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The diversity-oriented synthesis of imidazo[1, 2- a ][1, 3, 5]triazine derivatives from 2-amine-[1, 3, 5]triazines with ketones has been developed by tuning the reaction conditions. Abstract : An I2 -mediated annulation of 2-amino[1, 3, 5]triazines and ketones for the synthesis of imidazo[1, 2- a ][1, 3, 5]triazines is presented. Electron rich, or electron poor acetophenone and heterocycle ketones, as well as propiophenone, are functionalized with 2-amino-[1, 3, 5]triazines. Another class of imidazo[1, 2- a ][1, 3, 5]triazines tethered with an additional 1, 2-dicarbonyl motif through the combination of annulation and C–H functionalization were obtained instead by changing the reaction conditions. The new methods are practically straightforward and applicable on a gram scale.