Cobalt-catalyzed selective hydroacylation of alkynes. Issue 21 (9th September 2021)

• Record Type: Journal Article
• Authors: Wu, Jian; Gao, Wen-Xia; Huang, Xiao-Bo; Zhou, Yun-Bing; Liu, Miao-Chang; Wu, Hua-Yue
• Is Part Of: Organic chemistry frontiers. Volume 8:Issue 21(2021)
• Page Start: 6048
• Page End: 6052
• Publication Date: 2021-09-09
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d1qo00964h
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : An efficient protocol for alkyne hydroacylation using a catalytic system incorporating Co(acac)3, dppp and AlMe3 is disclosed. Abstract : An efficient protocol has been reported for alkyne hydroacylation using a catalytic system incorporating Co(acac)3, dppp and AlMe3 at 160 °C. The reaction proceeds through oxidative cyclization/β-H elimination to afford a series of α, β-unsaturated ketones. The present protocol features no need for chelating groups, the use of inexpensive and bench-stable precatalysts, and wide substrate scope.