Smaller hippocampal volume in APOE ε4 carriers independent of amyloid-β (Aβ) burden. (30th November 2021)

• Record Type: Journal Article
• Authors: Suh, Hwagyu; Lee, Young-Min; Park, Je-Min; Lee, Byung-Dae; Moon, Eunsoo; Jeong, Hee; Kim, Soo Yeon; Lee, Kang Yoon; Kim, Hak-Jin; Pak, Kyoungjune; Choi, Kyung-Un; Mun, Chi-Woong; Chung, Young-In
• Is Part Of: Psychiatry research. Volume 317(2021)
• Publication Date: 2021-11-30
• Subjects: Apolipoprotein E ε4 -- Hippocampal volume -- Aβ burden; Psychiatry -- Periodicals; Brain -- Imaging -- Periodicals; Psychiatry -- Periodicals; Diagnostic Imaging -- Periodicals; Psychiatrie -- Périodiques; Cerveau -- Imagerie pour le diagnostic -- Périodiques; 616.890754
• DOI: 10.1016/j.pscychresns.2021.111381
• Languages: English
• ISSNs: 0925-4927

Abstract

Highlights: APOE ε 4 is associated with both a smaller hippocampal volume and a greater amyloid deposition. APOE ε 4 genotype is associated with a smaller right and total hippocampal volume independent of A β burden. APOE ε 4 genotype may contribute to hippocampal neurodegeneration through A β independent mechanism. Abstract: Objective: To investigate the association of the APOE ε 4 genotype with hippocampal volume, independent of A β burden. Method: This cross-sectional study included 71 participants with mild cognitive impairment or mild AD. All participants were divided into carriers or non-carriers of the ε 4 allele. The main outcome was hippocampal volume measured using structural magnetic resonance imaging; 18 F-florbetaben positron emission tomography was additionally performed to investigate the association of APOE ε 4 genotype with hippocampal volumes, independently of A β burden. Analysis of covariance was conducted to compare the differences in hippocampal volumes between carriers and non-carriers of the ε 4 allele after controlling for global A β burden or local hippocampal A β burden. Results: The APOE ε 4 genotype was associated with a smaller right and total hippocampal volume (right: 3160.16 ± 365.71 vs. 3365.24 ± 434.88, p < 0.05; total: 6257.48 ± 790.60 vs. 6599.52 ± 840.58, p < 0.05), independent of A β burden. Conclusion: Our findings on the association of APOE ε 4 genotype with hippocampal volume independent of A β burden suggest that the APOE ε 4 genotype may contribute to hippocampal neurodegeneration through an A β -independent mechanism.