Copper-catalyzed three-component reaction of arylhydrazine hydrochloride, DABSO, and NFSI for the synthesis of arenesulfonyl fluorides. Issue 41 (4th October 2021)

• Record Type: Journal Article
• Authors: Pan, Qijun; Liu, Yongan; Pang, Wan; Wu, Jingjing; Ma, Xiaoyu; Hu, Xiaojun; Guo, Yong; Chen, Qing-Yun; Liu, Chao
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 41(2021)
• Page Start: 8999
• Page End: 9003
• Publication Date: 2021-10-04
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d1ob01697k
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A convenient copper-catalyzed conversion of phenylhydrazine hydrochlorides to arenesulfonyl fluorides in good yields under mild conditions. Abstract : This paper reports a convenient copper-catalyzed three-component conversion of arylhydrazine hydrochlorides to arenesulfonyl fluorides in good yields under mild conditions, using 1, 4-diazabicyclo [2.2.2]octane bis(sulfur dioxide) (DABSO) as a sulfonyl source and N -fluorobenzenesulfonimide (NFSI) as a fluorine source based on a radical sulfur dioxide insertion and fluorination strategy. Notably, arylhydrazine hydrochloride is used as a safe precursor of aryl radicals.