C3-Arylation of indoles with aryl ketones via C–C/C–H activations. Issue 76 (2nd September 2021)

• Record Type: Journal Article
• Authors: Guo, Zi-Qiong; Xu, Hui; Wang, Xing; Wang, Zhen-Yu; Ma, Biao; Dai, Hui-Xiong
• Is Part Of: Chemical communications. Volume 57:Issue 76(2021)
• Page Start: 9716
• Page End: 9719
• Publication Date: 2021-09-02
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc03954g
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : C3-Arylation of indoles with aryl ketones is accomplished via palladium-catalyzed ligand-promoted Ar–C(O) cleavage and subsequent C–H arylation of indole. Abstract : C3-Arylation of indoles with aryl ketones is accomplished via palladium-catalyzed ligand-promoted Ar–C(O) cleavage and subsequent C–H arylation of indole. Various (hetero)aryl ketones are compatible in this reaction, affording the corresponding 3-arylindoles in moderate to good yields. Further introduction of an indole moiety into the natural products desoxyestrone and evodiamine demonstrate the synthetic utility of this protocol.