Iron catalyzed β-C(sp2)–H alkylation of enamides. (2nd September 2021)

• Record Type: Journal Article
• Authors: Bertho, Sylvain; Maazaoui, Radhouan; Torun, Damla; Dondasse, Ismaël; Abderrahim, Raoudha; Nicolas, Cyril; Gillaizeau, Isabelle
• Is Part Of: New journal of chemistry. Volume 45:Number 37(2021)
• Page Start: 17475
• Page End: 17482
• Publication Date: 2021-09-02
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/d1nj03673d
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : An attractive and cheap alternative approach was developed for the β-C(sp 2 )–H (fluoro)alkylation of a range of cyclic and acyclic non-aromatic enamides using either FeCl2 as a catalyst or a stoichiometric amount of nontoxic iron powder. Abstract : An attractive and cheap alternative approach was developed for the β-C(sp 2 )–H (fluoro)alkylation of a range of cyclic and acyclic non-aromatic enamides using either FeCl2 as a catalyst or a stoichiometric amount of nontoxic iron powder. This reaction is regioselective and exhibits broad substrate scope and good functional group tolerance.