Coupling 6-chloro-3-methyluracil with copper: structural features, theoretical analysis, and biofunctional properties. Issue 38 (10th September 2021)

• Record Type: Journal Article
• Authors: Kumar, Brajesh; Das, Tushar; Das, Subhadeep; Maniukiewicz, Waldemar; Nesterov, Dmytro S.; Kirillov, Alexander M.; Das, Subrata
• Is Part Of: Dalton transactions. Volume 50:Issue 38(2021)
• Page Start: 13533
• Page End: 13542
• Publication Date: 2021-09-10
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/d1dt02018h
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : A unique copper(ii ) complex with 6-chloro-3-methyluracil was assembled and fully characterized, revealing a notable antibacterial and antioxidant activity. Abstract : As nucleobases in RNA and DNA, uracil and 5-methyluracil represent a recognized class of bioactive molecules and versatile ligands for coordination compounds with various biofunctional properties. In this study, 6-chloro-3-methyluracil (Hcmu) was used as an unexplored building block for the self-assembly generation of a new bioactive copper(ii ) complex, [Cu(cmu)2 (H2 O)2 ]·4H2 O (1 ). This compound was isolated as a stable crystalline solid and fully characterized in solution and solid state by a variety of spectroscopic methods (UV-vis, EPR, fluorescence spectroscopy), cyclic voltammetry, X-ray diffraction, and DFT calculations. The structural, topological, H-bonding, and Hirshfeld surface features of 1 were also analyzed in detail. The compound 1 shows a distorted octahedral {CuN2 O4 } coordination environment with two trans cmu − ligands adopting a bidentate N, O-coordination mode. The monocopper(ii ) molecular units participate in strong H-bonding interactions with water molecules of crystallization, leading to structural 0D → 3D extension into a 3D H-bonded network with a tfz-d topology. Molecular docking and ADME analysis as well as antibacterial and antioxidant activity studies were performed to assess the bioactivity of 1 . In particular, this compound exhibits a prominent antibacterial effect against Gram negative ( E. coli, P. aeruginosa ) and positive ( S. aureus, B. cereus ) bacteria. The obtained copper(ii ) complex also represents the first structurally characterized coordination compound derived from 6-chloro-3-methyluracil, thus introducing this bioactive building block into a family of uracil metal complexes with notable biofunctional properties.