Synthetic biology approaches in regulation of targeted gene expression. (October 2021)

• Record Type: Journal Article
• Authors: Huang, Debao; Kosentka, Pawel Z.; Liu, Wusheng
• Is Part Of: Current opinion in plant biology. Volume 63(2021)
• Publication Date: 2021-10
• Subjects: Synthetic biology -- Targeted gene expression -- Transcriptional regulation -- Post-transcriptional regulation -- Translational regulation -- Post-translational regulation; Plant molecular biology -- Periodicals; 571.205
• DOI: 10.1016/j.pbi.2021.102036
• Languages: English
• ISSNs: 1369-5266

Abstract

Abstract: Synthetic biology approaches are highly sought-after to facilitate the regulation of targeted gene expression in plants for functional genomics research and crop trait improvement. To date, synthetic regulation of gene expression predominantly focuses at the transcription level via engineering of synthetic promoters and transcription factors, while pioneering examples have started to emerge for synthetic regulation of gene expression at the levels of mRNA stability, translation, and protein degradation. This review discusses recent advances in plant synthetic biology for the regulation of gene expression at multiple levels, and highlights their future directions.