Copper(i)-catalyzed asymmetric intramolecular C-arylation with ureas as the additives: highly enantioselective formation of spirooxindoles. Issue 34 (23rd August 2021)

• Record Type: Journal Article
• Authors: Ma, Haowen; Feng, Jiajie; Zhou, Wei; Chen, Chen; Deng, Zhuoji; Zhou, Fengtao; Ouyang, Yifan; Zhang, Xinhao; Cai, Qian
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 34(2021)
• Page Start: 7480
• Page End: 7484
• Publication Date: 2021-08-23
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d1ob01327k
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A cooperative catalytic strategy is developed for a copper-catalyzed asymmetric intramolecular C-arylation reaction with ureas as the co-catalysts. Abstract : A cooperative catalytic strategy is developed for a copper-catalyzed asymmetric intramolecular C-arylation reaction with ureas as the co-catalysts. By forming hydrogen bonds with 1, 3-dicarbonyl structures, ureas can activate the substrates, stabilize the carbanion intermediates and the products, and fix the syn -configurations of 1, 3-dicarbonyl structures. They help enhance the reactivity, prevent side reactions and improve the enantioselectivities.