Early nociceptive evoked potentials (NEPs) recorded from the scalp. Issue 11 (November 2021)

• Record Type: Journal Article
• Authors: Leandri, Massimo; Di Stefano, Giulia; Truini, Andrea; Marinelli, Lucio
• Is Part Of: Clinical neurophysiology. Volume 132:Issue 11(2021)
• Page Start: 2896
• Page End: 2906
• Publication Date: 2021-11
• Subjects: Neurophysiology -- Nociception -- Pain -- Evoked Potentials -- Primary response -- Micropatterned; 150 IDE 150 μm InterDigitated Electrode -- 1000 IDE 1000 μm InterDigitated Electrode -- IASP International Association for the Study of Pain -- LEP(s) Laser Evoked Potential(s) -- PREP(s) Pain Related Evoked Potential(s) -- SEP(s) Somatosensory Evoked Potential(s) -- NEP(s) Nociceptive Evoked Potential(s) -- VAS Visual Analog Scale; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2021.05.027
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: Near nerve recordings confirmed selective stimulation of intraepidermal free nerve endings by the 150 IDE electrode. Early nociceptive evoked potentials (NEPs) were recorded from the contralateral scalp after 150 IDE stimulation. Early NEPs (component N40) possibly reflect the first cortical activation by fast nociceptive afferents. Abstract: Objective: Neurophysiological investigation of nociceptive pathway has so far been limited to late cortical responses. We sought to detect early components of the cortical evoked potentials possibly reflecting primary sensory activity. Methods: The 150 IDE micropatterned electrode was used to selectively activate Aδ intraepidermic fibres of the right hand dorsum in 25 healthy subjects and 3 patients suffering from trigeminal neuralgia. Neurographic recordings were performed to assess type of stimulated fibres and check selectivity. Cortical evoked potentials were recorded from C3′-Fz and Cz-Au1. Results: Neurographic recordings confirmed selective activation of Aδ fibres. Early components were detected after repetitive stimulation (0.83/s rate and 250–500 averages); the first negative component occured at 40 ms (N40) on the contralateral scalp. Conclusions: The provided data support the hypothesis that N40 could be the cortical primary response conducted by fast Aδ fibres. Significance: This is the first report of early, possibly primary, cortical responses in humans by nociceptive peripheral stimulation. Although not perfected yet to allow widespread diagnostic use, this is probably the only method to allow fully objective evaluation of the nociceptive system, with important future implications in experimental and clinical neurophysiology.