Measurement of the hyperelastic properties of 72 normal homogeneous and heterogeneous ex vivo breast tissue samples. (December 2021)

• Record Type: Journal Article
• Authors: Dempsey, Sergio C.H.; O'Hagan, Joseph J.; Samani, Abbas
• Is Part Of: Journal of the mechanical behavior of biomedical materials. Volume 124(2021)
• Publication Date: 2021-12
• Subjects: Breast tissue -- Fibroglandular tissue -- Adipose tissue -- Hyperelastic parameters -- Measurement -- Indentation technique; Biomedical materials -- Periodicals; Biomedical materials -- Mechanical properties -- Periodicals; Biomedical materials; Biomedical materials -- Mechanical properties; Periodicals; Electronic journals; 610.28
• DOI: 10.1016/j.jmbbm.2021.104794
• Languages: English
• ISSNs: 1751-6161

Abstract

Abstract: The mechanical properties of normal soft tissues, including breast tissue, have been of interest to the biomedical research community as there are many clinical and industrial applications that can benefit from quantitative information characterizing such properties. For instance, computer assisted surgery planning, elastography for breast cancer diagnosis, and bra design can all involve biomechanical modeling of the breast to predict its deformation or stress distribution. It is known that most biological soft tissues, including breast tissue, exhibit nonlinear mechanical response over large strains. As such, it is necessary to model such tissues as hyperelastic. In this work, we used indentation testing to estimate the hyperelastic parameters of 4 models (3rd order Ogden, 5-term polynomial, Veronda-Westman and Yeoh) estimated from 72 healthy ex vivo breast tissue samples covering adipose, fibroglandular, and mixed tissue. All estimated parameter sets were confirmed to represent stable material using Drucker's stability criterion. We observed that all three tissue types were statistically similar solidifying the use of homogenous breast modelling over large strain simulation.