Evaluation of dopamine transporter density in healthy Brazilians using Tc-99m TRODAT-1 SPECT. Issue 39 (1st October 2021)

• Record Type: Journal Article
• Authors: Reis, Marilia Alves dos; Gadelha, Ary; Felício, André C.; Hoexter, Marcelo Queiroz; Batista, Ilza Rosa; Braga-Neto, Pedro; Calzavara, Mariana; Cavagnolli, Daniel Alves; Higuchi, Cinthia; Leite, Melissa Furlaneto Lellis; Nogueira, Solange Amorim; Wagner, Jairo; Castiglioni, Mario Luiz Vieira; Shih, Ming Chi; Bressan, Rodrigo Affonseca
• Editors: Tusconi., Massimo
• Is Part Of: Medicine. Volume 100:Issue 39(2021)
• Page Start: e27192
• Publication Date: 2021-10-01
• Subjects: binding potential -- dopamine transporter -- healthy individuals -- single photon emission computed tomography -- technetium-99 metastable TRODAT-1; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000027192
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Abstract: The presynaptic dopamine transporter (DAT) modulates the uptake of dopamine by regulating its concentration in the central nervous system. We aimed to evaluate the DAT binding potential (DAT-BP) in a sample of healthy Brazilians through technetium-99 metastable TRODAT-1 single-photon emission computed tomography imaging. We selected 126 healthy individuals comprising 72 men and 54 women, aged 18 to 80 years. We conducted semi-quantitative evaluation in transaxial slices, following which we identified the regions of interest in the striatal region using the occipital lobe as a region of non-specific DAT-BP. We found a decrease in DAT-BP in healthy individuals aged over 30 years, culminating in a 42% mean reduction after 80 years. There was no difference in the decrease by age group between the right (linear regression test [ R 2 ] linear = 0.466) and left striatum ( R 2 linear = 0.510). Women presented a higher DAT-BP than men (women: R 2 linear = 0.431; men: R 2 linear = 0.457); nonetheless, their decrease by age group was equal to that in men. Our study sheds light on important DAT-BP findings in healthy Brazilian subjects. Our results will facilitate understanding of brain illnesses that involve the dopamine system, such as neuropsychiatric disorders.