Fulminant myocarditis and systemic hyperinflammation temporally associated with BNT162b2 mRNA COVID-19 vaccination in two patients. (1st October 2021)

• Record Type: Journal Article
• Authors: Abbate, Antonio; Gavin, Josh; Madanchi, Nima; Kim, Christin; Shah, Pranav R.; Klein, Katherine; Boatman, Julie; Roberts, Charlotte; Patel, Seema; Danielides, Stamatina
• Is Part Of: International journal of cardiology. Volume 340(2021)
• Page Start: 119
• Page End: 121
• Publication Date: 2021-10-01
• Subjects: Vaccine -- Myocarditis -- Coronavirus -- Covid-19; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2021.08.018
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Immune-mediated myocardial injury following Severe Acute Respiratory Syndrome Coronavirys-2 (SARS-CoV2) infection has been described in adults and children. Cases of myocarditis following immunization for SARS-CoV2 have recently been documented, mostly associated with mild severity and spontaneous recovery. We herein report two cases of fulminant myocarditis following BNT162b2 mRNA Covid-19 vaccination associated with systemic hyperinflammatory syndrome and refractory shock requiring support with veno-arterial extracorporeal membrane oxygenation. Highlights: Fulminant myocarditis may occur following SARS-CoV2 mRNA vaccination requiring mechanical cardiac support. It is important to recognize features of systemic hyperinflammatory syndrome following SARS-CoV2 mRNA vaccination.