Stimulus-responsive liposomes for biomedical applications. Issue 8 (August 2021)

• Record Type: Journal Article
• Authors: Antoniou, Antonia I.; Giofrè, Sabrina; Seneci, Pierfausto; Passarella, Daniele; Pellegrino, Sara
• Is Part Of: Drug discovery today. Volume 26:Issue 8(2021)
• Page Start: 1794
• Page End: 1824
• Publication Date: 2021-08
• Subjects: Liposomes -- Active targeting -- Internal stimuli -- Self-assembly -- Targeted drug delivery -- Nanocarriers -- Enzyme-responsive liposomes -- Redox-responsive liposomes -- pH-responsive liposomes -- Hypoxia-responsive liposomes -- Cancer therapy; AQ4N 1, 4-bis[[2-(dimethyloxidoamino)ethyl]amino]-5, 8-dihydroxy-9, 10-anthracenedione dihydrochloride -- ATRA All-trans retinoic acid -- β-CD β-cyclodextrin -- CD44 cluster of differentiation 44 -- CHEMS cholesteryl-hemisuccinate -- Chol cholesterol -- COL colchicine -- COS chitooligosaccharides -- CPP cell-penetrating peptide -- DDS drug delivery systems -- DOPC 1, 2-dioleoyl-sn-glycero-3-phosphocholine -- DOPE 1, 2-dioleoyl-sn-glycero-3-phosphoethanolamine -- DOX doxorubicin -- DPPC 1, 2-dipalmitoyl-sn-glycero-3-phosphocholine -- DSPE 1, 2-distearoyl-sn-glycero-3-phosphorylethanolamine -- DTX docetaxel -- EE% encapsulation efficiency -- EPC egg phosphatidylcholine -- FA folic acid -- GEM gemcitabine -- GSH glutathione -- HA hyaluronic acid -- HAase hyaluronidase -- HSPC hydrogenated soy phosphatidylcholine -- Hz hydrazone bond -- LPs liposomes -- MAA methacrylic acid -- MD-MA methoxy diethylene glycol methacrylate -- MMP matrix metalloproteinase -- MOMCs monocyte-derived multipotent cells -- mPEG methoxy polyethylene glycol -- mPEGB methyl ether polyethylene benzaldehyde -- NIN nintedanib -- ONL orthoester nucleoside lipid -- PC phosphatidylcholine -- pDNA plasmid DNA -- PDT photodynamic therapy -- PE phosphatidylethanolamine -- PEG polyethylene glycol -- PEtOz poly (2-ethyl-2-oxazoline) -- PFD pirfenidone -- pHSL pH sensitive liposome -- PLA phospholipase A -- PSC pancreatic stellate cell -- PTX paclitaxel -- R8 eight units of arginine -- RAR retinoic acid receptor -- RES reticuloendothelial system -- SA self-assembly -- SMA poly(styrene-co-maleic acid) -- sPLA2 secretory phospholipase A2 -- SSLP sterically stabilized LP -- TE transfection efficiency -- TEG tetraethyleneglycol; Drugs -- Design -- Periodicals; Drugs -- Research -- Periodicals; 615.1
• DOI: 10.1016/j.drudis.2021.05.010
• Languages: English
• ISSNs: 1359-6446

Abstract

Graphical abstract: Highlights: Recent advances in internal stimuli-responsive liposomes have been reported. Chemical modifications on liposomes pave the way to smart stimuli triggered drug delivery systems. Pro-drug/liposome-combined systems enhance the therapeutic efficacy of their biological cargo. Abstract: Liposomes are amphipathic lipidic supramolecular aggregates that are able to encapsulate and carry molecules of both hydrophilic and hydrophobic nature. They have been widely used as in vivo drug delivery systems for some time because they offer features such as synthetic flexibility, biodegradability, biocompatibility, low immunogenicity, and negligible toxicity. In recent years, the chemical modification of liposomes has paved the way to the development of smart liposome-based drug delivery systems, which are characterized by even more tunable and disease-directed features. In this review, we highlight the different types of chemical modification introduced to date, with a particular focus on internal stimuli-responsive liposomes and prodrug activation.