Sex, drugs, and anaesthesia research. (September 2021)

• Record Type: Journal Article
• Authors: Moody, Olivia A.; Vincent, Kathleen F.; Solt, Ken
• Is Part Of: British journal of anaesthesia. Volume 127:Number 3(2021)
• Page Start: 340
• Page End: 343
• Publication Date: 2021-09
• Subjects: anaesthetic pharmacology -- electroencephalogram -- hypnotic -- neurosteroid -- sex difference; Anesthesiology -- Periodicals; Anesthesia -- Periodicals; 617.9605
• DOI: 10.1016/j.bja.2021.06.025
• Languages: English
• ISSNs: 0007-0912

Abstract

Summary: In this issue of the British Journal of Anaesthesia, Joksimovic and colleagues report significant sex differences in sensitivity to the behavioural and neurophysiological effects of 3β-OH, a novel neurosteroid anesthetic. Female rats were more sensitive to the effects of 3β-OH than male rats, although the mechanims remain unclear. Sex differences have been understudied in anaesthesia research, and this article by Joksimovic and colleagues emphasizes the need to devote more effort to understanding these differences.