Can We AlphaFold Our Way Out of the Next Pandemic?. Issue 20 (1st October 2021)
- Record Type:
- Journal Article
- Title:
- Can We AlphaFold Our Way Out of the Next Pandemic?. Issue 20 (1st October 2021)
- Main Title:
- Can We AlphaFold Our Way Out of the Next Pandemic?
- Authors:
- Higgins, Matthew K.
- Abstract:
- Graphical abstract: Highlights: Many pathogen surface proteins undergo substantial conformational changes. Structural vaccinology often requires mapping of neutralising antibody epitopes. Structural insights allow antigen stabilisation or epitope grafting approaches. What contributions can AlphaFold 2 make to structure-guided immunogen design? Abstract: The announcement of the outstanding performance of AlphaFold 2 in the CASP 14 protein structure prediction competition came at the end of a long year defined by the COVID-19 pandemic. With an infectious organism dominating the world stage, the developers of Alphafold 2 were keen to play their part, accurately predicting novel structures of two proteins from SARS-CoV-2. In their blog post of December 2020, they highlighted this contribution, writing "we've also seen signs that protein structure prediction could be useful in future pandemic response efforts". So, what role does structural biology play in guiding vaccine immunogen design and what might be the contribution of AlphaFold 2?
- Is Part Of:
- Journal of molecular biology. Volume 433:Issue 20(2021)
- Journal:
- Journal of molecular biology
- Issue:
- Volume 433:Issue 20(2021)
- Issue Display:
- Volume 433, Issue 20 (2021)
- Year:
- 2021
- Volume:
- 433
- Issue:
- 20
- Issue Sort Value:
- 2021-0433-0020-0000
- Page Start:
- Page End:
- Publication Date:
- 2021-10-01
- Subjects:
- AlphaFold -- vaccine -- structure-guided immunogenicity design
Molecular biology -- Periodicals
Biology -- Periodicals
Biochemistry -- Periodicals
Bacteriology -- Periodicals
Molecular Biology -- Periodicals
Biochemistry -- Periodicals
Biologie moléculaire -- Périodiques
Biologie -- Périodiques
Biochimie -- Périodiques
Moleculaire biologie
Biochemistry
Biology
Molecular biology
Periodicals
572.805 - Journal URLs:
- http://www.sciencedirect.com/science/journal/00222836 ↗
http://www.elsevier.com/journals ↗ - DOI:
- 10.1016/j.jmb.2021.167093 ↗
- Languages:
- English
- ISSNs:
- 0022-2836
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 5020.700000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 19615.xml