Accuracy comparison of MR elastography and biological markers in detecting liver fibrosis and predicting postoperative ascites. Issue 9 (September 2021)

• Record Type: Journal Article
• Authors: Sato, Naoya; Kenjo, Akira; Nishimagi, Atsushi; Kimura, Takashi; Okada, Ryo; Ishigame, Teruhide; Kofunato, Yasuhide; Yamada, Shoki; Hashimoto, Yuko; Marubashi, Shigeru
• Is Part Of: HPB. Volume 23:Issue 9(2021)
• Page Start: 1383
• Page End: 1391
• Publication Date: 2021-09
• Subjects: Liver -- Diseases -- Periodicals; Biliary tract -- Diseases -- Periodicals; Pancreas -- Diseases -- Periodicals; 616.362005
• DOI: 10.1016/j.hpb.2021.01.011
• Languages: English
• ISSNs: 1365-182X

Abstract

Abstract: Background: This retrospective study aimed to compare the discriminative performance between magnetic resonance elastography (MRE) and biological markers in detecting liver fibrosis and in predicting postoperative ascites (PA). Methods: We enrolled 77 patients consecutively who underwent hepatectomy between March 2017 and June 2019. Liver fibrosis was histopathologically graded using the METAVIR scoring system as reference. Discriminative performance of non-invasive assessments in detecting different stages of liver fibrosis and predicting PA was evaluated by receiver–operator curve analysis. Results: The concordance indices (C-indices) for MRE and biological markers for detecting significant fibrosis (≥F2) and cirrhosis (F4) were: MRE, 0.84 and 0.86; Wisteria floribunda agglutinin + Mac-2 binding protein (WM2BP), 0.63 and 0.71; Hyaluronic acid (HA), 0.72 and 0.75; 7 S-type 4 collagen (T4C), 0.61 and 0.66; APRI, 0.76 and 0.83; and Fib-4, 0.75 and 0.76. Univariable logistic analysis for predicting PA showed that C-indices were 0.751 (p = 0.007), 0.798 (p = 0.106), 0.771 (p = 0.050), 0.674 (p = 0.855), 0.655 (p = 0.263), and 0.560 (p = 0.640) for MRE, WM2BP, Fib-4, HA, APRI, and T4C, respectively. Conclusion: MRE has a higher diagnostic performance than biological markers in detecting the stages of liver fibrosis and is a predictor for PA after hepatectomy.