Biofluids profile of α-Klotho in patients with Parkinson's disease. (September 2021)

• Record Type: Journal Article
• Authors: Sancesario, Giulia Maria; Di Lazzaro, Giulia; Grillo, Piergiorgio; Biticchi, Benedetta; Giannella, Emilia; Alwardat, Mohammad; Pieri, Massimo; Bernardini, Sergio; Mercuri, Nicola Biagio; Pisani, Antonio; Schirinzi, Tommaso
• Is Part Of: Parkinsonism & related disorders. Volume 90(2021)
• Page Start: 62
• Page End: 64
• Publication Date: 2021-09
• Subjects: α-Klotho -- CSF -- Blood -- Biomarkers -- Parkinson's disease; Parkinson's disease -- Periodicals; Movement disorders -- Periodicals; Movement Disorders -- Periodicals; Nerve Degeneration -- Periodicals; Nervous System Diseases -- Periodicals; Parkinson Disease -- Periodicals; Tremor -- Periodicals; Parkinson, Maladie de -- Périodiques; Parkinson's disease; 616.833
• DOI: 10.1016/j.parkreldis.2021.08.004
• Languages: English
• ISSNs: 1353-8020

Abstract

Abstract: We measured α-Klotho in CSF and serum of PD patients at early stage of the disease, finding two distinct pools, the first increased, the second reduced. CSF α-Klotho was inversely associated with CSF α-synuclein levels. Our preliminary results suggest α-Klotho as potential biomarker or therapeutic target in PD. Highlights: The anti-aging protein α-Klotho pathway is scarcely explored in vivo in PD . CSF α-Klotho was higher in PD patients and inversely correlated with CSF α-synuclein. Serum α-Klotho was reduced in PD patients independently from CSF markers. α-Klotho may be a biomarker or candidate target for neuroprotection in PD.