Rodent models used in preclinical studies of deep brain stimulation to rescue memory deficits. (November 2021)

• Record Type: Journal Article
• Authors: Faillot, Matthieu; Chaillet, Antoine; Palfi, Stéphane; Senova, Suhan
• Is Part Of: Neuroscience and biobehavioral reviews. Volume 130(2021)
• Page Start: 410
• Page End: 432
• Publication Date: 2021-11
• Subjects: 2VO Two- vessels occlusion -- 4-VO Four-vessels occlusion -- APP amyloid precursor protein -- atm Atmosphere -- AMPA alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid -- BCAO Bilateral Carotid Artery Occlusion -- BCAS Bilateral Carotid Artery Stenosis -- BOLD Blood-Oxygen-Level Dependent -- CA1 (2, 3, 4) Cornu Ammonis 1 (2, 3, 4) -- CCI controlled cortical impact -- ChAT choline acetyltransferase -- DAPI 4', 6-diamidino-2-phenylindole -- DBS deep brain stimulation -- DG dentate gyrus -- dMRI diffusion MRI -- DTI Diffusion Tensor Imaging -- ET-1 endothelin 1 -- EEG electroencephalogram -- FA Fractional Anisotropy -- fMRI functional MRI -- FST Forced SwimTest -- GABA gamma-aminobutyric acid -- GAD glutamic acid decarboxylase -- HE Hematoxylin Eosin -- Hz Hertz -- LFP local field potentials -- LTP long term potentiation -- MAP-2 microtubule associated protein 2 -- MCA Middle Cerebral Artery -- MCAO Middle Cerebral Artery Occlusion -- MEMRI Manganese Enhanced MRI -- MIMO Multi-input Multi-Output -- MMSE Mini Mental State Examination -- MOCA Montreal Cognitive Assessment -- mPFC medial Prefrontal Cortex -- MRI magnetic resonance imaging -- MS medial septum -- MWM Morris Water Maze -- NMDA N-methyl-D-aspartate -- PAC phase amplitude coupling -- PAT Passive Avoidance Task -- PET Positron Emission Tomography -- psi pound per square inch -- PTSD post traumatic stress disorder -- PV+ paravalbumine positive -- SOM+ somatostatin positive -- SWR sharp wave ripples -- TBI traumatic brain injury -- TST tail suspension test; Traumatic Brain Injury -- Stroke -- Rodent -- Deep Brain Stimulation -- Memory; Psychophysiology -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; Neurology -- Periodicals; Behavior -- Periodicals; Ethology -- Periodicals; Neurology -- Periodicals; Psychophysiologie -- Périodiques; Comportement humain -- Périodiques; Animaux -- Mœurs et comportement -- Périodiques; Neurologie -- Périodiques; Animal behavior; Human behavior; Neurology; Psychophysiology; Periodicals; Electronic journals; 573.8
• DOI: 10.1016/j.neubiorev.2021.08.012
• Languages: English
• ISSNs: 0149-7634

Abstract

Highlights: DBS is a promising treatment for memory deficits of patients with TBI and stroke. Proof of concept studies in rodent models of TBI and stroke are needed. High heterogeneity is observed among models, which mirrors the clinical variability. We review the histological, behavioral and electrophysiological findings observed in each model. We propose a translational framework to assess the efficacy of DBS in rodent models. Abstract: Deep brain stimulation paradigms might be used to treat memory disorders in patients with stroke or traumatic brain injury. However, proof of concept studies in animal models are needed before clinical translation. We propose here a comprehensive review of rodent models for Traumatic Brain Injury and Stroke. We systematically review the histological, behavioral and electrophysiological features of each model and identify those that are the most relevant for translational research.