Oncological relevance of major hepatectomy with inferior vena cava resection for intrahepatic cholangiocarcinoma. Issue 9 (September 2021)

• Record Type: Journal Article
• Authors: Palen, Anais; Garnier, Jonathan; Hobeika, Christian; Ewald, Jacques; Gregoire, Emilie; Delpero, Jean-Robert; Le Treut, Yves P.; Turrini, Olivier; Hardwigsen, Jean
• Is Part Of: HPB. Volume 23:Issue 9(2021)
• Page Start: 1439
• Page End: 1447
• Publication Date: 2021-09
• Subjects: Liver -- Diseases -- Periodicals; Biliary tract -- Diseases -- Periodicals; Pancreas -- Diseases -- Periodicals; 616.362005
• DOI: 10.1016/j.hpb.2021.02.007
• Languages: English
• ISSNs: 1365-182X

Abstract

Abstract: Background: This study aimed to investigate the short- and long-terms outcomes of patients undergoing major hepatectomy (MH) with inferior vena cava (IVC) resection for intrahepatic cholangiocarcinoma (ICC). Methods: Data from all patients who underwent MH for ICC with or without IVC resection between 2010 and 2018 were analysed retrospectively. Postoperative outcomes, overall survival (OS), and recurrence-free survival (RFS) were compared in the whole population. A propensity score matching (PSM) analysis and an inverse probability weighting analysis (IPW) were performed to assess the influence of IVC resection on short- and long-terms outcomes. Results: Among the 78 patients who underwent MH, 20 had IVC resection (IVC patients). Overall, the mortality and severe complication rate were 8% and 20%, respectively. IVC patients required more extended hepatectomies (p = 0.001) and had increased rates of transfusions (p = 0.001), however they did not experience increased postoperative morbidity, even after PSM. The 1-, 3- and 5-years OS and DFS were 78%, 45%, and 32% and 48%, 20%, and 16%, respectively. IVC was not associated with decreased OS (p = 0.52) and/or RFS (p = 0.85), even after IPW. Conclusion: MH with IVC resection for ICC seems to provide acceptable short- and long-term results in a selected population of patients.