A New Thiophene‐Appended Fluorescein‐Hydrazone‐Based Chromo‐Fluorogenic Sensor for the Screening of Hg2+ Ions in Real Water Samples. Issue 38 (12th October 2021)

• Record Type: Journal Article
• Authors: Roy, Swapnadip; Mondal, Tapashree; Dey, Dhananjay; Mane, Manoj V.; Panja, Sujit S.
• Is Part Of: ChemistrySelect. Volume 6:Issue 38(2021)
• Page Start: 10464
• Page End: 10479
• Publication Date: 2021-10-12
• Subjects: Chromo-fluorogenic sensor -- Hg(II) recognition -- PET -- Reversible binding -- Time-resolved fluorescence spectroscopy.; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202102692
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: A simple yet efficient, Hg 2+ selective sensor, based on a fluroescein‐thiophene conjugate, namely, (Z)‐3′, 6′‐dihydroxy‐2‐(((3‐methylthiophen‐2‐yl)methylene)amino)spiro[isoindoline‐1, 9′‐xanthen]‐3‐one (FT ) has been designed and synthesized. The compound was well characterized by analytical techniques such as HR‐MS, FTIR, UV‐visible absorption, steady‐state fluorescence and time‐resolved spectrophotometric techniques. Comprehensive analysis demonstrated FT as a highly specific and ultra‐sensitive sensor towards Hg 2+ ions in presence of several other interfering metal ions in ethanol/H2 O (9 : 1, v/v) at pH=7.2 buffered with 10 mM HEPES buffer at room temperature. The complexation of the probe FT with Hg 2+ was well confirmed by ESI‐MS and FTIR spectral analysis. The detection limit of the probe FT towards Hg 2+ was achieved down to 137 nM. The structure of ligand FT and FT ‐Hg 2+ complex were well corroborated by theoretical studies as well. In addition, the FT ‐Hg 2+ complex was found to be reversible in presence of di‐sodium EDTA and hence decipher its recyclability capabilities. The significance of the present probe FT lies in its successful application for the detection and quantification of Hg 2+ in real water samples and logic gate fabrication for future incorporation in small organic molecule based efficient molecular devices. Abstract : A new thiophene appended fluorescein‐hydrazone derivative (FT ) has been demonstrated as real‐time sensory system for Hg 2+ ions in aqueous medium. The detection limit of the probe FT towards Hg 2+ was 137 nM. The FT ‐Hg 2+ complex was found to be reversible in presence of EDTA. Significance of the probe lies in its successful application for the detection and quantification of Hg 2+ in real water samples and logic gate fabrication for future incorporation in small organic molecule based efficient molecular devices.