Sulfenylation of Indoles Mediated by Iodine and Its Compounds. Issue 38 (12th October 2021)

• Record Type: Journal Article
• Authors: Mulina, Olga M.; Ilovaisky, Alexey I.; Terent'ev, Alexander O.
• Is Part Of: ChemistrySelect. Volume 6:Issue 38(2021)
• Page Start: 10369
• Page End: 10378
• Publication Date: 2021-10-12
• Subjects: indole -- iodine -- oxidation -- reduction -- sulfenylation; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202102227
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Indole represents one of the most common and important heterocyclic scaffolds omnipresent in a plenty of natural products and medicinal agents. Development of the synthetic routes to 3‐substituted indoles attracts a considerable attention due to a huge amount of biologically relevant molecules containing 3‐substituted indole moiety. Reactions of indoles halogenation, nitration, acylation, and alkylation at the 3 d position have been known for several decades and continue developing now. Processes of indoles sulfenylation are much less studied. However, 3‐sulfenylated derivatives possess promising biological properties. This review summarizes nearly 100 references from the middle of the 20th century to 2021, concerning reactions of indoles sulfenylation mediated by iodine and its compounds. The manuscript is divided into the sections according to the classes of compounds used as sulfenylating agents. Abstract : 3‐Sulfenylated indoles possess unique biological properties. Direct sulfenylation of indole ring is the most simple way to them. During the last decades, iodine‐based systems are getting a significant attention for this transformation. This review summarizes data concerning reactions of indoles sulfenylation mediated by iodine and its compounds. The manuscript is divided into the chapters according to the classes of compounds used as sulfenylating agents.