Penalized regression for left‐truncated and right‐censored survival data. (24th July 2021)
- Record Type:
- Journal Article
- Title:
- Penalized regression for left‐truncated and right‐censored survival data. (24th July 2021)
- Main Title:
- Penalized regression for left‐truncated and right‐censored survival data
- Authors:
- McGough, Sarah F.
Incerti, Devin
Lyalina, Svetlana
Copping, Ryan
Narasimhan, Balasubramanian
Tibshirani, Robert - Abstract:
- Abstract : High‐dimensional data are becoming increasingly common in the medical field as large volumes of patient information are collected and processed by high‐throughput screening, electronic health records, and comprehensive genomic testing. Statistical models that attempt to study the effects of many predictors on survival typically implement feature selection or penalized methods to mitigate the undesirable consequences of overfitting. In some cases survival data are also left‐truncated which can give rise to an immortal time bias, but penalized survival methods that adjust for left truncation are not commonly implemented. To address these challenges, we apply a penalized Cox proportional hazards model for left‐truncated and right‐censored survival data and assess implications of left truncation adjustment on bias and interpretation. We use simulation studies and a high‐dimensional, real‐world clinico‐genomic database to highlight the pitfalls of failing to account for left truncation in survival modeling.
- Is Part Of:
- Statistics in medicine. Volume 40:Number 25(2021)
- Journal:
- Statistics in medicine
- Issue:
- Volume 40:Number 25(2021)
- Issue Display:
- Volume 40, Issue 25 (2021)
- Year:
- 2021
- Volume:
- 40
- Issue:
- 25
- Issue Sort Value:
- 2021-0040-0025-0000
- Page Start:
- 5487
- Page End:
- 5500
- Publication Date:
- 2021-07-24
- Subjects:
- Cox model -- high‐dimensional data -- lasso -- left truncation -- penalized regression -- survival analysis
Medical statistics -- Periodicals
Statistique médicale -- Périodiques
Statistiques médicales -- Périodiques
610.727 - Journal URLs:
- http://onlinelibrary.wiley.com/ ↗
- DOI:
- 10.1002/sim.9136 ↗
- Languages:
- English
- ISSNs:
- 0277-6715
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8453.576000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 19598.xml