FNDC4 acts as an extracellular factor to promote the invasiveness of hepatocellular carcinoma partly via the PI3K/Akt signalling pathway. (21st August 2021)

• Record Type: Journal Article
• Authors: Wang, Baolin; Zheng, Bowen; Lu, Yao; Huang, Deng; Liu, Jialong; Song, Juxian; Zheng, Shuguo
• Is Part Of: Cancer medicine. Volume 10:Number 20(2021)
• Page Start: 7242
• Page End: 7252
• Publication Date: 2021-08-21
• Subjects: extracellular domain -- FNDC4 -- HCC -- invasion -- PI3K/Akt; 616.994005
• DOI: 10.1002/cam4.4225
• Languages: English
• ISSNs: 2045-7634

Abstract

Abstract: FNDC4 is highly homologous to the exercise‐associated myokine FNDC5/irisin, which is highly expressed and promotes the invasion and metastasis of HCC cells. However, the function of FNDC4 remains unknown. Here, we report that FNDC4, an extracellular factor, plays important roles in the invasion and metastasis of HCC. We found that high FNDC4 expression is associated with poor survival in HCC patients and FNDC4 promotes the migration and invasion of HCC cells. Mechanistically, we found that FNDC4 is related to the PI3K/Akt signalling pathway to a certain extent. Specifically, the extracellular domain of FNDC4 acts as an extracellular factor to promote Akt phosphorylation levels in this pathway. These findings reveal that FNDC4 promotes the invasion and metastasis of HCC partly via the PI3K/Akt signalling pathway. Abstract : FNDC4 is differentially expressed in human HCC tissues, and high FNDC4 expression is significantly related to the poor prognosis of HCC.