Association of marital status with stage and survival in patients with mycosis fungoides: A population‐based study. (4th September 2021)

• Record Type: Journal Article
• Authors: Xing, Ling‐Xiao; Zhang, Jing; Shen, Hui; Tang, Xiao‐Lu; He, Lu; Wu, Jia‐Zhu; Li, Jian‐Yong; Miao, Yi
• Is Part Of: Cancer medicine. Volume 10:Number 20(2021)
• Page Start: 7320
• Page End: 7329
• Publication Date: 2021-09-04
• Subjects: marital status -- mycosis fungoides -- prognosis -- SEER; 616.994005
• DOI: 10.1002/cam4.4232
• Languages: English
• ISSNs: 2045-7634

Abstract

Abstract: Background: Previous studies have shown that marital status was associated with stages and survival in patients with melanoma or Merkel cell carcinoma. To date, the impacts of marital status on stage and survival in patients with mycosis fungoides (MF) have not been determined yet. Methods: A total of 3375 eligible cases diagnosed from 2004 to 2015 were included from the Surveillance, Epidemiology, and End Results (SEER) database. Association of marital status with stage and survival in patients with MF was analyzed. Results: Married patients were more likely to be diagnosed at T1 stage ( p = 0.041). And married patients were less likely to present with lymph node involvement ( p = 0.007). More favorable overall survival ( p < 0.001) and cancer‐specific survival ( p < 0.001) were demonstrated in married patients as compared with divorced patients or widowed patients. A clinically feasible prognostic model including marital status, age, sex, race, and stage at presentation was constructed. Conclusion: Married marital status was associated with earlier stage at diagnosis and longer survival compared with divorced or widowed marital status in patients with MF. Abstract : We found that married marital status was associated with earlier stage at diagnosis and longer survival compared with divorced or widowed marital status. A validated prognostic model that could be potentially used to stratify the patients with mycosis fungoides and guide clinical decision was constructed. Our study highlights the importance of inclusion of marital status as a prognostic factor in mycosis fungoides.