All‐in‐One Zeolite–Carbon‐Based Nanotheranostics with Adjustable NIR‐II Window Photoacoustic/Fluorescence Imaging Performance for Precise NIR‐II Photothermal‐Synergized Catalytic Antitumor Therapy. Issue 41 (9th September 2021)

• Record Type: Journal Article
• Authors: Zheng, Ziliang; Jia, Zhuo; Qin, Yufei; Dai, Rong; Chen, Xuejiao; Ma, Yanchun; Xie, Xianmei; Zhang, Ruiping
• Is Part Of: Small. Volume 17:Issue 41(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-09-09
• Subjects: catalytic therapy -- NIR‐II biowindow -- NIR‐II PA/NIR‐II FL imaging -- NIR‐II photothermal therapy -- zeolite–carbon‐based nanozymes; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202103252
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: In the second near‐infrared (NIR‐II) biowindow, multimodal optical imaging‐guided precise antitumor therapy is a novel strategy for high‐efficiency tumor theranostics, however, the all‐in‐one dual NIR‐II photoacoustic (NIR‐II PA) and NIR‐II fluorescence (NIR‐II FL) nanoprobes have been rarely reported mainly due to the short of a simple and universal design approach. Herein, a NIR‐II PA/NIR‐II FL imaging‐adjustable nanozyme (HSC‐2) is designed and developed to guide precise photothermal‐catalytic synergistic therapy. Based on the ionic liquids adsorption capacity, the electronic structure of zeolite nano‐Beta (three dimensional 12‐ring pore system and large surface area) can be turned from the indirect band gap to direct band gap via doping carbon in the framework, resulting in outstanding NIR‐II FL emission characteristics. As the silicon etching reaction proceeds, HSC‐2 shows superior dual‐modal NIR‐II PA/NIR‐II FL imaging performance facilitated by the optimal silicon‐to‐carbon ratio, simultaneously ensuring efficient tumor photothermal therapy (PTT) in the NIR‐II window. Impressively, the peroxidase‐mimic activity of HSC‐2 in the tumor microenvironment could be further remarkably enhanced by its photothermal effect, leading to excellent synergistic PTT/catalytic therapy. Moreover, the HSC‐2 exhibits dual‐enzyme activity, and its catalase‐like property could effectively eliminate excessive ROS for protection of the normal cells. Abstract : In this study, a novel NIR‐II PA/NIR‐II FL imaging‐adjustable nanozyme (HSC‐2) is designed and developed to guide precise photothermal‐catalytic synergistic therapy. By changing the silicon–carbon ratio in the framework, the nanozymes can effectively adjust the bandgap and surface N‐doped carbon content to ensure simultaneous optimization of the light absorption and emission in the NIR‐II window.