Ruthenium-106 brachytherapy for iris and iridociliary melanomas. Issue 8 (9th November 2017)

• Record Type: Journal Article
• Authors: Marinkovic, Marina; Horeweg, Nanda; Laman, Mirjam S; Bleeker, Jaco C; Ketelaars, Martijn; Peters, Femke P; Luyten, Gre P M; Creutzberg, Carien L
• Is Part Of: British journal of ophthalmology. Volume 102:Issue 8(2018)
• Page Start: 1154
• Page End: 1159
• Publication Date: 2017-11-09
• Subjects: iris -- ciliary body -- neoplasia -- treatment other -- vision; Ophthalmology -- Periodicals; 617.7
• DOI: 10.1136/bjophthalmol-2017-310688
• Languages: English
• ISSNs: 0007-1161

Abstract

Abstract : Background and purpose: To evaluate ruthenium-106 (Ru106) brachytherapy as eye-conserving treatment of iris melanomas (IMs) and iridociliary melanomas (ICMs). Materials and methods: Eighty-eight patients received Ru106 brachytherapy between 2006 and 2016. Primary outcome was local control, and secondary outcomes were metastasis, survival, eye preservation, complications and visual acuity (VA). Results: Overall median follow-up was 36 months. Of 88 patients, 58 (65.9%) had IM and 30 (34.1%) had ICM. ICM were on average larger and more advanced than IM. Local failure-free survival at 3years was 98.9% (SE 1.2%). Metastasis-free survival was 98.2% (SE 1.8%) at 3years; no deaths due to melanoma occurred during follow-up. Eye preservation rate was 97.7%. Treatment-related toxicities were mostly mild and observed in 80.7% of the patients. Common toxicities were worsening of pre-existing or new cataract (51.1%), dry eyes (29.5%) and glaucoma (20.5%). VA was not affected by Ru106 brachytherapy, with only 2.3% having VA <0.33 (low vision) at follow-up. Conclusions: Ru106 for IM and ICM yielded excellent local control (98.9%) and eye preservation (97.7%). Toxicities were common, but mostly mild and transient. Moreover, Ru106 did not affect visual acuity.