Synthesis, Antimicrobial Evaluation and Molecular Docking of New Functionalized Bis(1, 3, 4-Thiadiazole) and Bis(Thiazole) Derivatives. (21st October 2021)

• Record Type: Journal Article
• Authors: Mahmoud, Huda K.; Abbas, Ashraf A.; Gomha, Sobhi M.
• Is Part Of: Polycyclic aromatic compounds. Volume 41:Number 9(2021)
• Page Start: 2029
• Page End: 2041
• Publication Date: 2021-10-21
• Subjects: Antimicrobial activity -- bis(hydrazonoyl) chlorides -- bis(134-thiadiazoles) -- bis(thiazoles) -- coupling reactions; Polycyclic aromatic compounds -- Periodicals; 547
• DOI: 10.1080/10406638.2019.1709085
• Languages: English
• ISSNs: 1040-6638

Abstract

Abstract: Many bis-1, 3, 4-thiadiazoles 7, 10a, b, 13a-c and bis-thiazoles 16a-d, 19a-d were synthesized from reaction of bis(hydrazonoyl) chloride 4 with a series of methyl carbodithioate and thiosemicarbazone derivatives. Their antimicrobial activities were evaluated with six selected microorganisms. Some of the prepared derivatives showed higher antimicrobial activity than the reference used. Furthermore, molecular docking of the most active compound 10 b and the active site of target enzymes were studied using MOE 2014.010 software package.