Effect of Multiple Medicines on Dementia Initial Treatment: Experience and Thinking. (26th November 2021)

• Record Type: Journal Article
• Authors: Gan, Jinghuan; Wang, Meng; Liu, Shuai; Chen, Zhichao; Wang, Xiao-Dan; Ji, Yong
• Is Part Of: American journal of Alzheimer's disease & other dementias. Volume 36(2021)
• Publication Date: 2021-11-26
• Subjects: multiple medicines -- combination treatment -- cognitive impairment -- Alzheimer's disease -- anti-dementia prescription -- psychotropic medication; Alzheimer's disease -- Periodicals; Dementia -- Periodicals; Alzheimer's disease -- Patients -- Care -- United States -- Periodicals; 616.83
• DOI: 10.1177/15333175211053134
• Languages: English
• ISSNs: 1533-3175

Abstract

Little is known about multiple medicines and initial therapy among people with dementia. To examine the effect of multiple medicines on the initiation of anti-dementia therapy in patients diagnosed with cognitive impairment (CI), a retrospective study with 2742 CI patients was conducted based on the outpatients' medical records. The dementias receiving 1–2 drugs were more likely to be prescribed with anti-dementia (one drug: OR = 1.877; two drugs: OR = 1.770) and psychotropic (one drug: OR = 1.980) treatment, whereas had lower chances of receiving psychotropic medication with the combinations of more than three drugs (Alzheimer's disease: OR = .365; vascular dementia: OR = .940; frontotemporal lobe degeneration: OR = .957; and dementia with Lewy bodies/Parkinson's disease dementia: OR = .952). Multiple medicines can affect anti-dementia therapy initiation in dementia patients and should be paid extreme caution.