Effect of Low Dietary Vitamin D Fed Prior to and During Pregnancy and Lactation on Maternal Bone Mineral Density, Structure, and Strength in C57BL/6 Mice. Issue 10 (8th September 2021)

• Record Type: Journal Article
• Authors: Villa, Christopher R; Sacco, Sandra M; Chen, Jianmin; Taibi, Amel; Comelli, Elena M; Ward, Wendy E
• Is Part Of: Current developments in nutrition. Volume 5:Issue 10(2021)
• Publication Date: 2021-09-08
• Subjects: AIN-93 diets -- bone microarchitecture -- fracture -- micro-computed tomography -- calcium -- vitamin D; Nutrition -- Periodicals; Nutritional Physiological Phenomena; Nutrition; Periodicals; Periodicals; Fulltext; Internet Resources; Periodicals; 612.3
• DOI: 10.1093/cdn/nzab114
• Languages: English
• ISSNs: 2475-2991

Abstract

ABSTRACT: Several studies have shown that diets containing lower vitamin D than in the AIN-93G diet do not compromise bone structure, bone mineral density (BMD), and/or bone strength in male and female mice. This study determined if a diet containing low vitamin D from prepregnancy through to the end of lactation maintained these bone outcomes to a similar extent as a high vitamin D diet. Mice were fed an AIN-93G diet with 25 (LD diet) or 5000 (HD diet) IU vitamin D/kg diet from premating through to lactation ( n = 15/group). Of the major structure outcomes, only cortical area fraction of the distal femur was lower ( P <0.05) with the LD diet. Lumbar vertebra BMD was lower ( P <0.05) with LD whereas distal femur BMD and bone strength at 3 sites did not differ. Dams fed an LD diet premating through to the end of lactation had largely similar bone outcomes to dams fed a HD diet. Abstract : The study findings suggest that the level of bone-supporting nutrients such as vitamin D should be part of the conversation regarding a potential revision of the AIN-93 diets.