Spectrum of hospitalized NeuroCOVID diagnoses from a tertiary care neurology centre in Eastern India. (November 2021)

• Record Type: Journal Article
• Authors: Bhansali, Sakhi; Bagrodia, Vaishali; Choudhury, Supriyo; Rahman, Simin; Golder, Mohua; Tiwari, Mona; Kumar, Hrishikesh
• Is Part Of: Journal of clinical neuroscience. Volume 93(2021)
• Page Start: 96
• Page End: 102
• Publication Date: 2021-11
• Subjects: CSDH Chronic Subdural Hematoma -- SAH Subarachnoid Hemorrhage -- IVH Intraventricular Hemorrhage -- PCA Posterior Cerebral Artery -- MCA Middle Cerebral Artery -- AVM Arteriovenous Malformation -- ICH Intracerebral Hemorrhage -- CVT Cortical venous thrombosis -- VP Ventriculoperitoneal shunt -- D Dorsal vertebrae -- L Lumbar vertebrae -- PNS Peripheral Nervous System -- CIDP Chronic Inflammatory Demyelinating Polyneuropathy -- GBS Guillain-Barre Syndrome -- ICVA Ischemic Cerebrovascular Accident -- HCVA Hemorrhagic Cerebrovascular Accident -- SOL Space Occupying Lesions -- T2DM Type 2 Diabetes Mellitus -- IHD Ischemic Heart Disease -- CVA Cerebrovascular Accidents -- RT-PCR reverse-transcription polymerase chain reaction -- SPO2 Saturation of peripheral oxygen -- SARS-CoV-2 Severe Acute Respiratory Syndrome Coronavirus 2 -- TBI Traumatic Brain Injury -- SDH Subdural Hematoma -- EDH Epidural Hemorrhage -- PD Parkinson's Disease -- OR Odds Ratio -- CI Confidence Interval -- DENV Dengue Virus; NeuroCOVID -- COVID-19 -- SARS-CoV-2 -- Stroke -- Encephalopathy; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2021.09.008
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: Stroke and encephalopathy are common NeuroCOVID emergencies in India. NeuroCOVID can manifest without pre-existing systemic and neurological comorbidities. NeuroCOVID can occur concurrently or prior to classical features of COVID-19. Abstract: Purpose: To describe the spectrum of hospitalized NeuroCOVID on admission in a tertiary neurology centre in Kolkata, the largest and most populated metropolitan city in Eastern India. Method: We retrospectively studied confirmed COVID-19 patients admitted with a neurological condition from 1st May 2020 to 30th January 2021. Neurological diagnoses and their temporal relationship to respiratory features along with clinicodemographic profile for such patients was ascertained. Result: 228 patients were diagnosed with NeuroCOVID at our centre. Of the 162 included population (median age was 59 (50–70) and 62.3% (1 0 1) were male) and 73.5% were diagnosed with NeuroCovid before any respiratory or febrile features. 46 patients (28.8%) had a pre/co-existing neurological illness, and 103 (63.6%) had systemic comorbidities. No significant difference was observed when comparing demographics and comorbidities of NeuroCOVID patients presenting with and without fever and respiratory features. Moreover, no individual NeuroCOVID diagnosis was more prone to present with respiratory or febrile features. Diabetes mellitus was the only comorbidity which was significantly higher in the ischemic stroke group, all other comorbidities and characteristics were evenly distributed between stroke and non-stroke NeuroCOVID patients and encephalopathy non encephalopathy NeuroCOVID patients. Conclusion: Stroke and encephalopathy are the most prevalent parainfectious neurological conditions occurring with COVID-19 in the Indian population. This study demonstrates seemingly low-risk individuals (i.e. people without pre-existing systemic and neurological comorbidities) may develop neurological conditions. Moreover, NeuroCOVID may manifest independent of respiratory features and fever.