Dairy protein intake is inversely related to development of non-alcoholic fatty liver disease. Issue 10 (October 2021)

• Record Type: Journal Article
• Authors: Lee, Jun-Hyuk; Lee, Hye Sun; Ahn, Sang Bong; Kwon, Yu-Jin
• Is Part Of: Clinical nutrition. Volume 40:Issue 10(2021)
• Page Start: 5252
• Page End: 5260
• Publication Date: 2021-10
• Subjects: Milk proteins -- Dairy products -- Non-alcoholic fatty liver disease; Critically ill -- Nutrition -- Periodicals; Diet therapy -- Periodicals; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; Enteral Nutrition -- Periodicals; Parenteral Nutrition -- Periodicals; Metabolism -- Periodicals; Diétothérapie -- Périodiques; Alimentation parentérale -- Périodiques; Alimentation entérale -- Périodiques; Nutrition -- Périodiques; Diet therapy; Enteral feeding; Nutrition; Parenteral feeding; Electronic journals; Periodicals; Electronic journals; 615.854
• DOI: 10.1016/j.clnu.2021.08.012
• Languages: English
• ISSNs: 0261-5614

Abstract

Summary: Background & aims: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and is closely related to metabolic dysfunction, including insulin resistance, obesity, and metabolic syndrome. Dairy protein, rich in casein and whey protein, could help to reduce metabolic diseases. Therefore, we investigated the relationship between dairy protein intake and incident NAFLD. Methods: We analyzed data for 5171 adults aged 40–69 years from the Korean Genome and Epidemiology Study.(KoGES) Participants were separated as men, women aged ≥50 years, and women aged <50 years and then divided into tertiles based on dairy protein intake. NAFLD was defined as NAFLD liver fat score > − 0.640. Scores were calculated as 1.18 × metabolic syndrome (Yes: 1, No: 0) + 0.45 × diabetes mellitus (Yes: 2, No: 0) + 0.15 × serum insulin +0.04 × AST − 0.94 × (AST/ALT) − 2.89. Cox proportional hazards spline curves were drawn to visualize dose-response relationships between dairy protein intake and incident NAFLD. Multiple Cox hazard regression analysis was conducted to examine associations between dairy protein intake and incident NAFLD. Results: The Cox proportional hazards spline curves revealed a negative linear relationship between dairy protein intake and incident NAFLD. The cumulative incidence of NAFLD significantly decreased with increasing tertiles of dairy protein intake in men and women aged ≥50 years. After adjusting for confounding factors, the hazard ratios and 95% confidence intervals for NAFLD in the middle and highest tertiles, compared to the lowest tertile, were 0.80 (0.67–0.96) and 0.71 (0.57–0.88) in men, 0.89 (0.72–1.09) and 0.72 (0.56–0.92) in women aged ≥50 years, and 1.01 (0.80–1.27) and 0.91 (0.67–1.24) in women aged <50 years, respectively. Conclusions: We found that higher dairy protein intake was significantly and inversely associated with the risk of incident NAFLD in men and women aged ≥50 years. Consumption of milk and other dairy products could help prevent the development of NAFLD.